Financial toxicity in patients with glioblastoma Journal Article


Authors: Terrell, D.; Camarano, J.; Whipple, S.; Guthikonda, B.; Beyl, R.; Newman, W. C.
Article Title: Financial toxicity in patients with glioblastoma
Abstract: Purpose: There has been mounting interest in understanding the impact of financial toxicity (FT) in various cancer types; however, it remains poorly understood and understudied within neuro-oncology—especially as it relates to neurosurgical components of patient care. Methods: Retrospective, single-center study of patients who underwent craniotomy for resection of glioblastoma from 2020 to 2022. OIBEETM (Austin, Texas) software was queried to identify the subset of these patients who had a bad debt charged to their account. These patients were deemed to qualify as experiencing FT. Chi Square analysis was conducted between FT and non-FT patient groups. Additionally, survival analyses were performed to determine predictors of progression free and overall survival. Results: 74 patients were included in this sample. 33/74 (44%) met criteria for FT. The average bad debt amount was $7,476.76 and the median debt amount was $2,015.96, with the average time to financial toxicity after surgery being approximately 127 days. FT patients were significantly younger at diagnosis than those who were not FT (64.6 years- non-FT vs. 59.0 years- FT, p = 0.0344). FT patients were more likely to have undergone subtotal resections rather than a gross total resection compared to non-FT patients (FT GTR 27.3%, non-FT GTR 52.4%, p = 0.028). Hospital length of stay was significantly longer for FT patients compared to non-FT patients (LOS FT 9.5 days, non-FT 6.5 days, p = 0.0312). Conclusion: Glioblastoma patients are at high risk of experiencing FT with our series showing no significant impact on overall survival. Larger studies are needed to understand the impact of FT on patient outcomes. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.
Keywords: adult; aged; middle aged; survival analysis; survival rate; retrospective studies; overall survival; mortality; nuclear magnetic resonance imaging; brain tumor; follow up; brain neoplasms; follow-up studies; cancer diagnosis; progression free survival; tumor volume; oncology; retrospective study; economics; patient care; length of stay; body mass; glioblastoma; surgery; craniotomy; transurethral resection; coronary artery disease; chronic kidney failure; adverse event; neuro-oncology; humans; prognosis; human; male; female; article; financial toxicity; financial distress; icd-10; financial stress; t1 weighted imaging; nursing home mortality; neurosurgical oncology
Journal Title: Journal of Neuro-Oncology
Volume: 171
Issue: 1
ISSN: 0167-594X
Publisher: Springer  
Date Published: 2025-01-01
Start Page: 75
End Page: 83
Language: English
DOI: 10.1007/s11060-024-04835-8
PUBMED: 39412733
PROVIDER: scopus
DOI/URL:
Notes: Article -- Source: Scopus
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  1. William Christopher Newman
    24 Newman