Feasibility and acceptability of a mindfulness app-based intervention among patients with metastatic renal cell carcinoma: A multinational study Journal Article


Authors: Bergerot, C. D.; Bergerot, P. G.; Philip, E. J.; Malhotra, J.; Castro, D. V.; Govindarajan, A.; Fuzita, W. H.; da Silva França, M. V.; de Azeredo, A. C.; dos Anjos, G. M.; de Araujo, R.; Hsu, J.; Chawla, N.; Chehrazi-Raffle, A.; Buso, M. M.; Saab, B.; Carlson, L. E.; Pal, S. K.
Article Title: Feasibility and acceptability of a mindfulness app-based intervention among patients with metastatic renal cell carcinoma: A multinational study
Abstract: Background: Patients with metastatic renal cell carcinoma (mRCC) experience emotional distress and limited supportive care access. This study assesses a mindfulness app’s feasibility, acceptability, and preliminary efficacy in improving emotional symptoms, trait mindfulness, and overall quality of life for patients with mRCC on immunotherapy. Methods: This multinational study recruited patients with mRCC undergoing immunotherapy from Brazil and the United States. Participants were required to engage in mindfulness app-based activities for 20–30 min daily, at least 4 days per week, over a 4-week period. Assessments were conducted at weeks 0, 2, 4, and 12 to evaluate emotional symptoms (PROMIS-Anxiety and Depression, Fear of Cancer Recurrence-7), fatigue (Brief Fatigue Inventory), trait mindfulness (Mindfulness Attention Awareness Scale), and quality of life (Functional Assessment of Chronic Illness Therapy-General). Self-reported data were used to assess adherence. Linear mixed-effects models were used to evaluate changes over time for the measured outcomes. Results: Among 50 patients with mRCC, the feasibility of this intervention was demonstrated; 96% of patients were assessed at week 4, with high adherence rates reported by 75% of patients. Participants expressed positive feedback on the smartphone-based approach. Significant improvements were observed in emotional symptoms, fatigue, and quality of life scores from baseline to post-intervention (P = .001 for each), suggesting the positive impact of this intervention. Conclusion: Our findings provide encouraging evidence for the feasibility and acceptability of a mindfulness app-based intervention among patients with mRCC. This intervention may offer a viable and accessible means of providing psychosocial support to patients with mRCC. © The Author(s) 2025. Published by Oxford University Press.
Journal Title: The Oncologist
Volume: 30
Issue: 1
ISSN: 1083-7159
Publisher: Oxford University Press  
Date Published: 2025-01-17
Start Page: oyae309
Language: English
DOI: 10.1093/oncolo/oyae309
PUBMED: 39820635
PROVIDER: scopus
PMCID: PMC11740315
DOI/URL:
Notes: Article -- Source: Scopus
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