Exercise and Nutrition to Improve Cancer Treatment-Related Outcomes (ENICTO) Editorial
| Authors: | Schmitz, K. H.; Brown, J. C.; Irwin, M. L.; Robien, K.; Scott, J. M.; Berger, N. A.; Caan, B.; Cercek, A.; Crane, T. E.; Evans, S. R.; Ligibel, J. A.; Meyerhardt, J. A.; Agurs-Collins, T.; Basen-Engquist, K.; Bea, J. W.; Cai, S. F.; Cartmel, B.; Chinchilli, V. M.; Demark-Wahnefried, W.; Dieli-Conwright, C. M.; DiPietro, L.; Doerksen, S. E.; Edelstein, S. L.; Elena, J.; Evans, W.; Ferrucci, L. M.; Foldi, J.; Freylersythe, S.; Furberg, H.; Jones, L. W.; Levine, R.; Moskowitz, C. S.; Owusu, C.; Penedo, F.; Rabin, B. A.; Ratner, E.; Rosenzweig, M.; Salz, T.; Sanft, T.; Schlumbrecht, M.; Spielmann, G.; Thomson, C. A.; Tjaden, A. H.; Weiser, M. R.; Yang, S.; Yu, A. F.; Perna, F. M.; for the ENICTO Consortium |
| Title: | Exercise and Nutrition to Improve Cancer Treatment-Related Outcomes (ENICTO) |
| Abstract: | Chemotherapy treatment-related side effects are common and increase the risk of suboptimal outcomes. Exercise interventions during cancer treatment improve self-reported physical functioning, fatigue, anxiety, and depression, but it is unclear whether these interventions improve important clinical outcomes, such as chemotherapy relative dose intensity. The National Cancer Institute funded the Exercise and Nutrition to Improve Cancer Treatment-Related Outcomes (ENICTO) Consortium to address this knowledge gap. This article describes the mechanisms hypothesized to underpin intervention effects on clinically relevant treatment outcomes, briefly outlines each project’s distinct research aims, summarizes the scope and organizational structure of ENICTO, and provides an overview of the integrated common data elements used to pursue research questions collectively. In addition, the article includes a description of consortium-wide activities and broader research community opportunities for collaborative research. Findings from the ENICTO Consortium have the potential to accelerate a paradigm shift in oncology care such that patients with cancer could receive exercise and nutrition programming as the standard of care in tandem with chemotherapy to improve relative dose intensity for a curative outcome. © The Author(s) 2024. |
| Keywords: | treatment outcome; fatigue; review; antineoplastic agents; united states; antineoplastic agent; neoplasm; nutritional status; neoplasms; quality of life; exercise; cancer therapy; national cancer institute (u.s.); body composition; therapy; national health organization; kinesiotherapy; organizational structure; nutrition; etiology; clinical outcome; exercise therapy; humans; human; common data elements; knowledge gap |
| Journal Title: | JNCI: Journal of the National Cancer Institute |
| Volume: | 117 |
| Issue: | 1 |
| ISSN: | 0027-8874 |
| Publisher: | Oxford University Press |
| Date Published: | 2025-01-01 |
| Start Page: | 9 |
| End Page: | 19 |
| Language: | English |
| DOI: | 10.1093/jnci/djae177 |
| PUBMED: | 39118255 |
| PROVIDER: | scopus |
| PMCID: | PMC11717426 |
| DOI/URL: | |
| Notes: | Review -- Source: Scopus |
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