Defining spine cancer pain syndromes: A systematic review and proposed terminology Review
| Authors: | Pahuta, M.; Laufer, I.; Lo, S. F. L.; Boriani, S.; Fisher, C.; Dea, N.; Weber, M. H.; Chou, D.; Sahgal, A.; Rhines, L.; Reynolds, J.; Lazary, A.; Gasbarrinni, A.; Verlaan, J. J.; Gokaslan, Z.; Bettegowda, C.; Sarraj, M.; Barzilai, O.; and On behalf of the AO Spine Knowledge Forum Tumor |
| Review Title: | Defining spine cancer pain syndromes: A systematic review and proposed terminology |
| Abstract: | Study Design: Systematic Review. Objectives: Formalized terminology for pain experienced by spine cancer patients is lacking. The common descriptors of spine cancer pain as mechanical or non-mechanical is not exhaustive. Misdiagnosed spinal pain may lead to ineffective treatment recommendations for cancer patients. Methods: We conducted a systematic review of pain terminology that may be relevant to spinal oncology patients. We provide a comprehensive and unbiased summary of the existing evidence, not limited to the spine surgery literature, and subsequently consolidate these data into a practical, clinically relevant nomenclature for spine oncologists. Results: Our literature search identified 3515 unique citations. Through title and abstract screening, 3407 citations were excluded, resulting in 54 full-text citations for review. Pain in cancer patients is typically described as nociceptive pain (somatic vs visceral), neurologic pain and treatment related pain. Conclusions: We consolidate the terminology used in the literature and consolidated into clinically relevant nomenclature of biologic tumor pain, mechanical pain, radicular pain, neuropathic pain, and treatment related pain. This review helps standardize terminology for cancer-related pain which may help clinicians identify pain generators. © The Author(s) 2024. |
| Keywords: | cancer chemotherapy; osteolysis; pathophysiology; cancer patient; cancer radiotherapy; pain; peripheral neuropathy; bone pain; cancer pain; systematic review; brain derived neurotrophic factor; diagnostic error; electromyography; nomenclature; headache; cytokine release; paraneoplastic syndrome; postoperative pain; peripheral nerve; burning sensation; nociception; pain threshold; spine metastasis; low back pain; neuralgia; spine surgery; spinal metastasis; spinal pain; intracranial hypertension; radiculopathy; oncologist; tumor invasion; spine cancer; neurotrophin; nerve conduction; nerve compression; radicular pain; pain syndrome; visceral pain; human; article; nociceptive pain; transcutaneous electrical nerve stimulation; lumbosacral plexopathy; preferred reporting items for systematic reviews and meta-analyses; central pain syndrome; data quality assessment |
| Journal Title: | Global Spine Journal |
| Volume: | 15 |
| Issue: | 1 Suppl. |
| ISSN: | 2192-5682 |
| Publisher: | Georg Thieme Verlag |
| Date Published: | 2025-01-01 |
| Start Page: | 81S |
| End Page: | 92S |
| Language: | English |
| DOI: | 10.1177/21925682241259686 |
| PROVIDER: | scopus |
| PMCID: | PMC11726517 |
| PUBMED: | 39801118 |
| DOI/URL: | |
| Notes: | Article -- Source: Scopus |
