Management of lower urinary tract symptoms during the treatment for non-muscle invasive bladder cancer Review
| Authors: | Seiden, B.; Ajay, D.; Cheung, F.; Clements, M.; Pietzak, E. |
| Review Title: | Management of lower urinary tract symptoms during the treatment for non-muscle invasive bladder cancer |
| Abstract: | Purpose of Review: This narrative review aims to report upon the existing treatment evidence and strategies for managing lower urinary tract symptoms (LUTS) during treatment, including transurethral resection and intravesical therapy. This review also attempts to examine novel approaches to mitigate treatment-related lower urinary tract symptoms and improve treatment adherence. Recent Findings: There is sparse but promising evidence in improving LUTS secondary to intravesical therapy. Oral agents including phenazopyridine and hyaluronic acid, Bacillus Calmette-Guerin dose reduction, and emerging therapies including beta-3 agonists as well as Onabotulinumtoxin A injections all have demonstrated encouraging improvement in LUTS in limited research. Summary: Although recent literature explores new medications and potential strategies for managing intravesical therapy–related LUTS, further research is required to establish efficacy and new consensus on treatment strategies. Further research is also required to establish effective LUTS mitigation strategies with other emerging intravesical therapy regimens. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024. |
| Keywords: | constipation; review; cancer recurrence; placebo; drug dose comparison; drug dose reduction; drug withdrawal; nonhuman; side effect; gemcitabine; bcg vaccine; low drug dose; systematic review; urine incontinence; celecoxib; cardiovascular disease; dosage schedule comparison; tumor recurrence; dementia; patient compliance; xerostomia; cognitive defect; acupuncture; interstitial cystitis; urinary urgency; hyaluronic acid; drug administration; drug therapy; cystitis; mitomycin; levofloxacin; antibiotic prophylaxis; adverse drug reaction; therapy; meta analysis; ofloxacin; dysuria; intravesical drug administration; botulinum toxin a; lower urinary tract symptom; muscle invasive bladder cancer; pirarubicin; isoniazid; sustained drug release; intravesical therapy; iontophoresis; non muscle invasive bladder cancer; oxybutynin; phenazopyridine; lower urinary tract symptoms; transurethral resection of the bladder; human; pentosan polysulfate; mirabegron; pollakisuria; erdafitinib; beta 3 adrenergic receptor stimulating agent; solifenacin; trospium chloride |
| Journal Title: | Current Urology Reports |
| Volume: | 26 |
| Issue: | 1 |
| ISSN: | 1527-2737 |
| Publisher: | Springer |
| Date Published: | 2025-01-06 |
| Start Page: | 24 |
| Language: | English |
| DOI: | 10.1007/s11934-024-01250-4 |
| PUBMED: | 39760811 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Source: Scopus |
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