Synchronous pulmonary langerhans cell histiocytosis and multiple cutaneous reticulohistiocytomas with a common BRAF- V600E/D mutation driver Journal Article
| Authors: | Parra, O.; Georgantzoglou, N.; Green, D.; Wilson, J. G.; Linos, K. |
| Article Title: | Synchronous pulmonary langerhans cell histiocytosis and multiple cutaneous reticulohistiocytomas with a common BRAF- V600E/D mutation driver |
| Abstract: | Histiocytoses constitute a group of heterogeneous disorders characterized by involvement of variable organs by neoplastic macrophage or dendritic cells. They may affect both adults and children with a predilection to the skin, bone, lungs, lymph nodes, and CNS. The coexistence of different types of histiocytoses in the same patient is an extremely rare phenomenon. We describe a very rare case of co-occurring pulmonary Langerhans cell histiocytosis with multiple cutaneous reticulohistiocytomas with a common BRAF-V600E mutation as the driver genetic event in both the lung and skin lesions. The presence of a common BRAF-V600E mutation provides evidence of their clonal relation and contributes to our understanding in the pathogenesis of multiple, co-occurring histiocytic proliferations. |
| Keywords: | histiocytosis; juvenile; braf; xanthogranuloma; lesions; pathways; braf mutations; langerhans; erdheim-chester disease; rosai-dorfman-disease; cooccurrence; reticulohistiocytoma |
| Journal Title: | American Journal of Dermatopathology |
| Volume: | 47 |
| Issue: | 1 |
| ISSN: | 0193-1091 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2025-01-01 |
| Start Page: | 30 |
| End Page: | 35 |
| Language: | English |
| ACCESSION: | WOS:001376063800009 |
| DOI: | 10.1097/dad.0000000000002871 |
| PROVIDER: | wos |
| PUBMED: | 39498902 |
| Notes: | Article -- Source: Wos |
