The utility of BSND immunohistochemistry in the differential diagnosis of oncocytic and warthin-like mucoepidermoid carcinoma of salivary gland Journal Article
| Authors: | Xu, B.; Jungbluth, A.; Frosina, D.; Alabkaa, A.; Serrette, R.; Qin, H.; Roy, D.; Ghossein, R.; Katabi, N. |
| Article Title: | The utility of BSND immunohistochemistry in the differential diagnosis of oncocytic and warthin-like mucoepidermoid carcinoma of salivary gland |
| Abstract: | Purpose: BSND is a chloride channel subunit that is expressed in the normal salivary gland. We aimed to validate the utility of BSND immunohistochemistry in the differential diagnosis of oncocytic salivary gland neoplasms. Methods: BSND immunohistochemistry was performed in a retrospective cohort of 93 salivary gland lesions, enriched with tumors with oncocytic features and histologic variants of mucoepidermoid carcinoma (MEC). Results: All oncocytomas (n = 18) showed diffuse membranous BSND immunopositivity. Warthin tumors (n = 18) were also positive for BSND, but the staining pattern was patchy cytoplasmic and membranous in 10–25% of tumor cells. Using a threshold of 10% BSND-positive cells, all Warthin tumors were positive, while none of Warthin-like MECs or non-MEC salivary tumors were positive. Applying the same 10% positivity criterion, two oncocytic MECs were positive for BSND. The percentage of BSND staining in oncocytic MECs was up to 20%. In contrast, BSND was diffusely positive in oncocytomas with a median percentage of positivity of 95% (range: 40 − 100%). Therefore, a higher threshold of > 20% BSND-positive cells may be considered when differentiating between oncocytoma and oncocytic MEC. Conclusion: BSND immunohistochemistry is a potentially useful diagnostic marker for salivary gland neoplasms, especially oncocytic and Warthin-like MECs. A threshold of ≥ 10% positivity can differentiate Warthin tumors from Warthin-like MECs, whereas > 20% positivity can be effective for separating oncocytomas from oncocytic MECs. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024. |
| Keywords: | immunohistochemistry; adolescent; adult; aged; aged, 80 and over; middle aged; retrospective studies; young adult; metabolism; diagnosis, differential; differential diagnosis; pathology; retrospective study; tumor marker; oncocytoma; adenoma, oxyphilic; diagnosis; salivary gland tumor; carcinoma, mucoepidermoid; salivary gland neoplasms; mucoepidermoid carcinoma; chloride channel; very elderly; mucoepidermoid tumor; humans; human; male; female; chloride channels; warthin tumor; biomarkers, tumor; adenolymphoma; bsnd immunohistochemistry |
| Journal Title: | Head and Neck Pathology |
| Volume: | 18 |
| Issue: | 1 |
| ISSN: | 1936-055X |
| Publisher: | Humana Press Inc |
| Date Published: | 2024-12-01 |
| Start Page: | 123 |
| Language: | English |
| DOI: | 10.1007/s12105-024-01728-0 |
| PUBMED: | 39589616 |
| PROVIDER: | scopus |
| PMCID: | PMC11599517 |
| DOI/URL: | |
| Notes: | Article -- MSK Cancer Center Support Grant (P30 CA008748) acknowledged in PubMed and PDF -- MSK corresponding author is Nora Katabi -- Source: Scopus |
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