Targeted therapy for breast cancer Book Section


Authors: Atieh, D. M.; Vahdat, L. T.
Editors: Kaufman, H. L.; Wadler, S.; Antman, K.
Article/Chapter Title: Targeted therapy for breast cancer
Title Series: Cancer Drug Discovery and Development
Abstract: With the completion of human genome project, the confluence of information on drivers of cell proliferation and the emergence of technology to define and produce therapeutics, molecularly targeted therapies are beginning to be integrated into the overall treatment of patients with cancer. This chapter focuses on the development, mechanism of action, and clinical utility of these agents in breast cancer. Monoclonal antibodies (trastuzumab, bevacizumab, and cetiximab), small molecule tyrosine kinase and farnesyl transferase inhibitors (gefitinib, erlotinib, lapatinib, and tipifarnib), mammalian target of rapamycin and Raf kinase inhibitors (temsirolimus, everolimus, and sorafenib), and other novel agents (ZD 6474, SU 11248) are discussed. In addition, the use of molecular taxonomy and microarray analysis in predicting outcomes and response to therapy are reviewed.
Keywords: cell proliferation
Book Title: Molecular Targeting in Oncology
ISBN: 978-1-58829-577-4
Publisher: Humana Press Inc  
Publication Place: Totowa, NJ
Date Published: 2008-01-01
Start Page: 309
End Page: 342
Language: English
ACCESSION: BIOSIS:PREV200800346455
PROVIDER: biosis
DOI: 10.1007/978-1-59745-337-0_19
Notes: --- - Book Chapter 14 - "Source: Biosis"
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MSK Authors
  1. Deena Mary Atieh Graham
    4 Graham