T cells standing at the gates of brain metastasis Editorial
| Authors: | Remsik, J.; Boire, A. |
| Title: | T cells standing at the gates of brain metastasis |
| Abstract: | Insufficient influx of T cells into the tumor microenvironment, including brain metastasis, dramatically limits efficacy of conventional immunotherapy. In this issue of Immunity, Messmer et al. interrogate spatiotemporal dependencies of melanoma brain metastasis T cell infiltration by intravital microscopy. They find that T cells enter these brain tumors through peritumoral venous vessels and can be stimulated with immunotherapy. © 2024 Elsevier Inc. |
| Keywords: | immunohistochemistry; nonhuman; note; brain tumor; brain neoplasms; t lymphocyte; tumor associated leukocyte; lymphocytes, tumor-infiltrating; t-lymphocytes; mouse; animal; animals; mice; cancer immunotherapy; melanoma; cell infiltration; pathology; endothelium cell; immunology; immunotherapy; brain metastasis; adoptive transfer; tumor growth; intravital microscopy; therapy; intercellular adhesion molecule 1; cancer transplantation; tumor microenvironment; procedures; humans; human; melanoma brain metastasis |
| Journal Title: | Immunity |
| Volume: | 57 |
| Issue: | 11 |
| ISSN: | 1074-7613 |
| Publisher: | Cell Press |
| Date Published: | 2024-11-12 |
| Start Page: | 2491 |
| End Page: | 2493 |
| Language: | English |
| DOI: | 10.1016/j.immuni.2024.10.006 |
| PUBMED: | 39536714 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Note -- Source: Scopus |
