Immune-mediated neurological syndromes associated with childhood cancers Review
| Authors: | Rossor, T.; Tewari, S.; Gadian, J.; Kaliakatsos, M.; Angelini, P.; Lim, M. |
| Review Title: | Immune-mediated neurological syndromes associated with childhood cancers |
| Abstract: | The association of recognisable neurological conditions with an underlying malignancy is well described. In this review we explore the complex interplay of genetic, environmental and tumour factors which contribute to autoimmunity and paraneoplastic conditions. We review the current understanding of the pathogenesis of well recognised paraneoplastic conditions in children including Opsoclonus myoclonus ataxia syndrome, N-Methyl-D Aspartate receptor encephalitis and limbic encephalitis, and the broad approaches to treatment. Rapid advances in oncological treatment has expanded the arsenal of therapeutic modalities. We explore the broad spectrum of immune therapies in childhood cancer, and the potential neurological complications of these novel therapies, and discuss the fine balance of risk and benefit that these bring. © 2024 The Authors |
| Keywords: | child; pathogenesis; review; side effect; cancer therapy; childhood cancer; immunotherapy; autoimmunity; drug therapy; encephalitis; paraneoplastic syndrome; neurological complication; neurologic disease; nerve cell; adverse drug reaction; therapy; intravenous drug administration; n methyl dextro aspartic acid receptor; opsoclonus myoclonus syndrome; motor neuron disease; paraneoplastic; limbic encephalitis; immune therapy; human; paediatric oncology; neoplastic cell transformation; neurological immune related adverse events; paediatric neurology |
| Journal Title: | European Journal of Paediatric Neurology |
| Volume: | 53 |
| ISSN: | 1090-3798 |
| Publisher: | Elsevier Ltd |
| Date Published: | 2024-10-31 |
| Start Page: | 174 |
| End Page: | 181 |
| Language: | English |
| DOI: | 10.1016/j.ejpn.2024.10.013 |
| PROVIDER: | scopus |
| PUBMED: | 39547086 |
| DOI/URL: | |
| Notes: | Review -- Source: Scopus |
