The intersection of the oral microbiome and salivary metabolites in head and neck cancer: From diagnosis to treatment Review

   


Authors: Gonzalez Agurto, M.; Olivares, N.; Canedo-Marroquin, G.; Espinoza, D.; Tortora, S. C.
Review Title: The intersection of the oral microbiome and salivary metabolites in head and neck cancer: From diagnosis to treatment
Abstract: Head and neck cancers (HNCs) represent 4–5% of all malignancies globally. Salivary metabolites, as metabolic intermediates and signalling molecules, are gaining attention as diagnostic biomarkers for several diseases, including HNC; however, the metabolites’ role in cancer treatment outcomes and oral side effects remains underexplored. Current studies focus on the oral microbiome’s significance in promoting a pro-inflammatory environment that facilitates tumour development and invasion. Specific microorganisms and their metabolites influence chemotherapy efficacy through several mechanisms. Radiotherapy (RT), a standard HNC treatment, can modify the oral microbiota and salivary metabolite profiles, leading to a wide range of side effects. To reduce oral complications, intensity-modulated radiotherapy (IMRT) was developed; however, cancer survivors often experience a reduced quality of life. This review highlights the microbial and host interactions affecting salivary metabolites and their implications for cancer treatment and patient outcomes. © 2024 by the authors.
Keywords: signal transduction; treatment outcome; review; intensity modulated radiation therapy; nonhuman; side effect; biological marker; quality of life; radiotherapy; inflammation; cancer survivor; head and neck cancer; diagnosis; drug therapy; adverse drug reaction; metabolite; mucin; metabolites; saliva; mouth flora; microbiome; human; dysbiosis; oral microbiota; neoplastic cell transformation
Journal Title: Cancers
Volume: 16
Issue: 20
ISSN: 2072-6694
Publisher: MDPI  
Date Published: 2024-10-02
Start Page: 3545
Language: English
DOI: 10.3390/cancers16203545
PROVIDER: scopus
PMCID: PMC11506592
PUBMED: 39456639
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85207640517&doi=10.3390%2fcancers16203545&partnerID=40&md5=e8c530a655af62a3d1ca795eac20f540
Notes: Review -- Source: Scopus
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