Standardization of scan protocols for RT CT simulator from different vendors using quantitative image quality technique Journal Article


Authors: Kuo, H. C.; Mahmood, U.; Kirov, A. S.; Trotman, T.; Lin, S. C.; Mechalakos, J. G.; Della Biancia, C.; Cerviño, L. I.; Lim, S. B.
Article Title: Standardization of scan protocols for RT CT simulator from different vendors using quantitative image quality technique
Abstract: Objective: To investigate the feasibility of standardizing RT simulation CT scanner protocols between vendors using target-based image quality (IQ) metrics. Method and materials: A systematic assessment process in phantom was developed to standardize clinical scan protocols for scanners from different vendors following these steps: (a) images were acquired by varying CTDIvol and using an iterative reconstruction (IR) method (IR: iDose and model-based iterative reconstruction [IMR] of CTp-Philips Big Bore scanner, SAFIRE of CTs-Siemens biograph PETCT scanner), (b) CT exams were classified into body and brain protocols, (c) the rescaled noise power spectrum (NPS) was calculated, (d) quantified the IQ change due to varied CTDIvol and IR, and (e) matched the IR strength level. IQ metrics included noise and texture from NPS, contrast, and contrast-to-noise ratio (CNR), low contrast detectability (d′). Area under curve (AUC) of the receiver operation characteristic curve of d′ was calculated and compared. Results: The level of change in the IQ ratio was significant (>0.6) when using IMR. The IQ ratio change was relatively low to moderate when using either iDose in CTp (0.1–0.5) or SAFIRE in CTs (0.1–0.6). SAFIRE-2 in CTs showed a closer match to the reference body protocol when compared to iDose-3 in CTp. In the brain protocol, iDose-3 in CTp could be matched to the low to moderate level of SAFIRE in CTs. The AUC of d′ was highest when using IMR in CTp with lower CTDIvol, and SAFIRE in CTs performed better than iDose in CTp. Conclusion: It is possible to use target-based IQ metrics to evaluate the performance of the system and operations across various scanners in a phantom. This can serve as an initial reference to convert clinical scanned protocols from one CT simulation scanner to another. © 2024 The Author(s). Journal of Applied Clinical Medical Physics published by Wiley Periodicals LLC on behalf of American Association of Physicists in Medicine.
Keywords: intensity modulated radiation therapy; neoplasm; neoplasms; radiotherapy dosage; radiotherapy; signal noise ratio; tomography, x-ray computed; diagnostic imaging; algorithms; algorithm; computer assisted diagnosis; radiotherapy, intensity-modulated; radiotherapy planning, computer-assisted; phantoms, imaging; image processing, computer-assisted; image processing; radiographic image interpretation, computer-assisted; devices; procedures; iterative reconstruction; tomography scanners, x-ray computed; nps; signal-to-noise ratio; imaging phantom; humans; human; radiotherapy planning system; detectability; x-ray computed tomography; ct scanner; ttf
Journal Title: Journal of Applied Clinical Medical Physics
Volume: 25
Issue: 10
ISSN: 1526-9914
Publisher: American College of Medical Physics  
Date Published: 2024-10-01
Start Page: e14484
Language: English
DOI: 10.1002/acm2.14484
PUBMED: 39137027
PROVIDER: scopus
PMCID: PMC11466467
DOI/URL:
Notes: The MSK Cancer Center Support Grant (P30 CA008748) is acknowledge in the PDF -- Corresponding authors is MSK author: Hsiang-Chi Kuo -- Source: Scopus
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MSK Authors
  1. Seng Boh Lim
    90 Lim
  2. Assen Kirov
    89 Kirov
  3. Usman Ahmad Mahmood
    46 Mahmood
  4. Hsiang-Chi Kuo
    21 Kuo
  5. Shih-Chi Lin
    5 Lin