Accelerating accessibility of CAR-T/NK therapies – Are AlloCARs and rapid manufacturing platforms the road ahead in improving access in multiple myeloma? Review

  


Authors: Rajeeve, S.; Hoskote, A.; Mailankody, S.
Review Title: Accelerating accessibility of CAR-T/NK therapies – Are AlloCARs and rapid manufacturing platforms the road ahead in improving access in multiple myeloma?
Abstract: While the advent of CAR-T therapies has heralded a new era of efficacious therapies in relapsed/refractory Multiple Myeloma, access continues to be a major limiting factor due to prolonged manufacturing times of autologous products and apheresis and/or manufacturing failures. Allogeneic adoptive cellular therapy products (CAR-T, CAR-NK), currently investigational, are “off-the-shelf” products that may address availability and manufacturing bottlenecks. Novel rapid manufacturing platforms that decrease adoptive cell therapy product development time by weeks are currently being tested in clinical trials and may additionally help bridge the demand-supply chasm. This review provides a comprehensive overview of allogeneic adoptive cellular therapies and rapid manufacturing platforms in development. © 2024 Elsevier Inc.
Keywords: reproducibility; gene targeting; multiple myeloma; dendritic cell; b lymphocyte; immunology; graft versus host reaction; chimeric antigen receptor; natural killer cell; killer cells, natural; macrophage; therapy; adoptive immunotherapy; immunotherapy, adoptive; health care access; product development; health services accessibility; drug manufacture; apheresis; lymphocyte subpopulation; procedures; humans; human; article; car-t; gene editing; chimeric antigen receptor t-cell immunotherapy; chimeric antigen receptor natural killer cell immunotherapy; receptors, chimeric antigen; cell therapy agent; access to treatment; allocar; rapid manufacturing; relapsed/refractory multiple myeloma (rrmm)
Journal Title: Seminars in Hematology
Volume: 61
Issue: 5
ISSN: 0037-1963
Publisher: W.B. Saunders Co-Elsevier Inc.  
Date Published: 2024-10-01
Start Page: 297
End Page: 305
Language: English
DOI: 10.1053/j.seminhematol.2024.09.001
PUBMED: 39370354
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85205692167&doi=10.1053%2fj.seminhematol.2024.09.001&partnerID=40&md5=ea281f81de37fca0e5ba2b40e32c5ed0
Notes: Source: Scopus
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MSK Authors
  1. Sham Mailankody
    293 Mailankody
  2. Sridevi Rajeeve
    41 Rajeeve
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