Proteomic basis for pancreatic acinar cell carcinoma and pancreatoblastoma as similar yet distinct entities Journal Article
| Authors: | Tanaka, A.; Ogawa, M.; Zhou, Y.; Hendrickson, R. C.; Miele, M. M.; Li, Z.; Klimstra, D. S.; Wang, J. Y.; Roehrl, M. H. A. |
| Article Title: | Proteomic basis for pancreatic acinar cell carcinoma and pancreatoblastoma as similar yet distinct entities |
| Abstract: | Acinar cell carcinoma (ACC) and pancreatoblastoma (PBL) are rare pancreatic malignancies with acinar differentiation. Proteogenomic profiling of ACC and PBL revealed distinct protein expression patterns compared to pancreatic ductal adenocarcinoma (PDAC) and benign pancreas. ACC and PBL exhibited similarities, with enrichment in proteins related to RNA processing, chromosome organization, and the mitoribosome, while PDACs overexpressed proteins associated with actin-based processes, extracellular matrix, and immune-active stroma. Pathway activity differences in metabolic adaptation, epithelial-to-mesenchymal transition, and DNA repair were characterized between these diseases. PBL showed upregulation of Wnt-CTNNB1 and IGF2 pathways. Seventeen ACC-specific proteins suggested connections to metabolic diseases with mitochondrial dysfunction, while 34 PBL-specific proteins marked this pediatric cancer with an embryonic stem cell phenotype and alterations in chromosomal proteins and the cell cycle. This study provides novel insights into the proteomic landscapes of ACC and PBL, offering potential targets for diagnostic and therapeutic development. © The Author(s) 2024. |
| Keywords: | signal transduction; human tissue; unclassified drug; histone deacetylase inhibitor; antineoplastic agent; cell cycle; protein protein interaction; alkylating agent; enzyme inhibitor; retrospective study; proteomics; protein tyrosine kinase inhibitor; nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase inhibitor; upregulation; mammalian target of rapamycin inhibitor; protein inhibitor; tumor microenvironment; epithelial mesenchymal transition; pancreatic ductal carcinoma; dna methyltransferase inhibitor; pancreatoblastoma; adrenergic receptor blocking agent; polo like kinase inhibitor; prostaglandin synthase inhibitor; peroxisome proliferator activated receptor agonist; telomere homeostasis; hormone receptor stimulating agent; acinar cell carcinoma of the pancreas; human; article; endothelin receptor antagonist; serotonin agonist; estrogen receptor antagonist; adenosine triphosphatase inhibitor; proteogenomics; isocitrate dehydrogenase inhibitor; sodium channel blocking agent; calcium channel stimulating agent; chemokine receptor antagonist; dipeptidyl peptidase inhibitor; glucocorticoid receptor agonist; leukocyte elastase inhibitor; nedd activating enzyme inhibitor; nucleophosmin inhibitor; oxytocin receptor agonist; peptide hydrolase inhibitor; purinergic receptor blocking agent; cell stemness |
| Journal Title: | npj Precision Oncology |
| Volume: | 8 |
| ISSN: | 2397-768X |
| Publisher: | Springer Nature |
| Date Published: | 2024-10-03 |
| Start Page: | 221 |
| Language: | English |
| DOI: | 10.1038/s41698-024-00708-5 |
| PROVIDER: | scopus |
| PMCID: | PMC11449907 |
| PUBMED: | 39363045 |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledge in the PDF -- Source: Scopus |
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