Leptomeningeal metastases from solid tumors: A Society for Neuro-Oncology and American Society of Clinical Oncology consensus review on clinical management and future directions Review
| Authors: | Wilcox, J. A.; Chukwueke, U. N.; Ahn, M. J.; Aizer, A. A.; Bale, T. A.; Brandsma, D.; Brastianos, P. K.; Chang, S.; Daras, M.; Forsyth, P.; Garzia, L.; Glantz, M.; Oliva, I. C. G.; Kumthekar, P.; Le Rhun, E.; Nagpal, S.; O'Brien, B.; Pentsova, E.; Lee, E. Q.; Remsik, J.; Rudà, R.; Smalley, I.; Taylor, M. D.; Weller, M.; Wefel, J.; Yang, J. T.; Young, R. J.; Wen, P. Y.; Boire, A. A. |
| Review Title: | Leptomeningeal metastases from solid tumors: A Society for Neuro-Oncology and American Society of Clinical Oncology consensus review on clinical management and future directions |
| Abstract: | Leptomeningeal metastases (LM) are increasingly becoming recognized as a treatable, yet generally incurable, complication of advanced cancer. As modern cancer therapeutics have prolonged the lives of patients with metastatic cancer, specifically in patients with parenchymal brain metastases, treatment options, and clinical research protocols for patients with LM from solid tumors have similarly evolved to improve survival within specific populations. Recent expansions in clinical investigation, early diagnosis, and drug development have given rise to new unanswered questions. These include leptomeningeal metastasis biology and preferred animal modeling, epidemiology in the modern cancer population, ensuring validation and accessibility of newer leptomeningeal metastasis diagnostics, best clinical practices with multimodality treatment options, clinical trial design and standardization of response assessments, and avenues worthy of further research. An international group of multi-disciplinary experts in the research and management of LM, supported by the Society for Neuro-Oncology and American Society of Clinical Oncology, were assembled to reach a consensus opinion on these pressing topics and provide a roadmap for future directions. Our hope is that these recommendations will accelerate collaboration and progress in the field of LM and serve as a platform for further discussion and patient advocacy. © 2024 The Author(s). Published by Oxford University Press on behalf of the Society for Neuro-Oncology. |
| Keywords: | systemic therapy; united states; neoplasm; neoplasms; consensus; pathology; oncology; societies, medical; meningeal neoplasms; medical society; medical oncology; radiation therapy; disease management; carcinomatous meningitis; therapy; consensus guideline; leptomeningeal metastases; meningeal carcinomatosis; leptomeningeal disease; procedures; humans; human; intrathecal therapy; meningeal tumor |
| Journal Title: | Neuro-Oncology |
| Volume: | 26 |
| Issue: | 10 |
| ISSN: | 1522-8517 |
| Publisher: | Oxford University Press |
| Date Published: | 2024-10-01 |
| Start Page: | 1781 |
| End Page: | 1804 |
| Language: | English |
| DOI: | 10.1093/neuonc/noae103 |
| PUBMED: | 38902944 |
| PROVIDER: | scopus |
| PMCID: | PMC11449070 |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledge in the PDF -- Corresponding authors is MSK author: Adrienne Boire -- Source: Scopus |
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