Predicting standardized uptake value of brown adipose tissue from CT scans using convolutional neural networks Journal Article
| Authors: | Erdil, E.; Becker, A. S.; Schwyzer, M.; Martinez-Tellez, B.; Ruiz, J. R.; Sartoretti, T.; Vargas, H. A.; Burger, A. I.; Chirindel, A.; Wild, D.; Zamboni, N.; Deplancke, B.; Gardeux, V.; Maushart, C. I.; Betz, M. J.; Wolfrum, C.; Konukoglu, E. |
| Article Title: | Predicting standardized uptake value of brown adipose tissue from CT scans using convolutional neural networks |
| Abstract: | The standard method for identifying active Brown Adipose Tissue (BAT) is [18F]-Fluorodeoxyglucose ([18F]-FDG) PET/CT imaging, which is costly and exposes patients to radiation, making it impractical for population studies. These issues can be addressed with computational methods that predict [18F]-FDG uptake by BAT from CT; earlier population studies pave the way for developing such methods by showing some correlation between the Hounsfield Unit (HU) of BAT in CT and the corresponding [18F]-FDG uptake in PET. In this study, we propose training convolutional neural networks (CNNs) to predict [18F]-FDG uptake by BAT from unenhanced CT scans in the restricted regions that are likely to contain BAT. Using the Attention U-Net architecture, we perform experiments on datasets from four different cohorts, the largest study to date. We segment BAT regions using predicted [18F]-FDG uptake values, achieving 23% to 40% better accuracy than conventional CT thresholding. Additionally, BAT volumes computed from the segmentations distinguish the subjects with and without active BAT with an AUC of 0.8, compared to 0.6 for CT thresholding. These findings suggest CNNs can facilitate large-scale imaging studies more efficiently and cost-effectively using only CT. © The Author(s) 2024. |
| Keywords: | adult; controlled study; aged; middle aged; major clinical study; diagnostic accuracy; radiopharmaceuticals; metabolism; computer assisted tomography; image analysis; cohort analysis; body weight; obesity; tomography, x-ray computed; diagnostic imaging; prediction; radiation exposure; body mass; health status; drug uptake; tomography; quantitative analysis; fluorodeoxyglucose f 18; fluorodeoxyglucose f18; radiopharmaceutical agent; segmentation; histogram; qualitative analysis; artificial neural network; standardized uptake value; image segmentation; brown adipose tissue; procedures; adipose tissue, brown; endocrine system disorder; x-ray tomography; predictive model; humans; human; male; female; article; cold exposure; x-ray computed tomography; convolutional neural network; positron emission tomography-computed tomography; positron emission tomography computed tomography; accuracy assessment; neural networks, computer |
| Journal Title: | Nature Communications |
| Volume: | 15 |
| ISSN: | 2041-1723 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2024-09-27 |
| Start Page: | 8402 |
| Language: | English |
| DOI: | 10.1038/s41467-024-52622-w |
| PUBMED: | 39333526 |
| PROVIDER: | scopus |
| PMCID: | PMC11436835 |
| DOI/URL: | |
| Notes: | Erratum issued, see DOI: 10.1038/s41467-024-54209-x -- Source: Scopus |
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