Clinical and genomic characterization of ERBB2-altered gallbladder cancer: Exploring differences between an American and a Chilean cohort Journal Article


Authors: Mondaca, S.; Walch, H.; Sepúlveda, S.; Schultz, N.; Muñoz, G.; Yaqubie, A.; Macanas, P.; Pareja, C.; Garcia, P.; Chatila, W.; Nervi, B.; Li, B.; Harding, J. J.; Viviani, P.; Roa, J. C.; Abou-Alfa, G. K.
Article Title: Clinical and genomic characterization of ERBB2-altered gallbladder cancer: Exploring differences between an American and a Chilean cohort
Abstract: PURPOSE: Gallbladder cancer (GBC) is a biliary tract malignancy characterized by its high lethality. Although the incidence of GBC is low in most countries, specific areas such as Chile display a high incidence. Our collaborative study sought to compare clinical and molecular features of GBC cohorts from Chile and the United States with a focus on ERBB2 alterations. METHODS: Patients were accrued at Memorial Sloan Kettering Cancer Center (MSK) or the Pontificia Universidad Católica de Chile (PUC). Clinical information was retrieved from medical records. Genomic analysis was performed by the next-generation sequencing platform MSK-Integrated Mutation Profiling of Actionable Cancer Targets. RESULTS: A total of 260 patients with GBC were included, 237 from MSK and 23 from PUC. There were no significant differences in the clinical characteristics between the patients identified at MSK and at PUC except in terms of lithiasis prevalence which was significantly higher in the PUC cohort (85% v 44%; P = .0003). The prevalence of ERBB2 alterations was comparable between the two cohorts (15% v 9%; P = .42). Overall, ERBB2 alterations were present in 14% of patients (8% with ERBB2 amplification, 4% ERBB2 mutation, 1.5% concurrent amplification and mutation, and 0.4% ERBB2 fusion). Notably, patients with GBC that harbored ERBB2 alterations had better overall survival (OS) versus their ERBB2-wild type counterparts (22.3 months v 11.8 months; P = .024). CONCLUSION: The prevalence of lithiasis seems to be higher in Chilean versus US patients with GBC. A similar prevalence of ERBB2 alterations of overall 14% and better OS suggests that a proportion of them could benefit from human epidermal growth factor receptor type 2-targeted therapies. The smaller cohort of Chile, where the disease prevalence is higher, is a reminder and invitation for the need of more robust next-generation sequencing analyses globally.
Keywords: adult; aged; aged, 80 and over; middle aged; genetics; mutation; mortality; united states; comparative study; cohort studies; epidermal growth factor receptor 2; cohort analysis; pathology; genomics; receptor, erbb-2; epidemiology; gallbladder neoplasms; chile; erbb2 protein, human; gallbladder tumor; high throughput sequencing; high-throughput nucleotide sequencing; very elderly; humans; human; male; female
Journal Title: JCO Global Oncology
Volume: 10
ISSN: 2687-8941
Publisher: American Society of Clinical Oncology  
Date Published: 2024-10-01
Start Page: e2400090
Language: English
DOI: 10.1200/go.24.00090
PUBMED: 39388662
PROVIDER: scopus
PMCID: PMC11487998
DOI/URL:
Notes: Article -- Source: Scopus
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MSK Authors
  1. James Joseph Harding
    250 Harding
  2. Ghassan Abou-Alfa
    569 Abou-Alfa
  3. Nikolaus D Schultz
    487 Schultz
  4. Amin Taher Yaqubie
    23 Yaqubie
  5. Bob Tingkan Li
    278 Li
  6. Walid Khaled Chatila
    102 Chatila
  7. Henry Stuart Walch
    100 Walch