Synapse - Universal germline genetic testing in patients with hematologic malignancies using DNA isolated from nail clippings

Universal germline genetic testing in patients with hematologic malignancies using DNA isolated from nail clippings Research Letter

Authors:	Ceyhan-Birsoy, O.; Fiala, E.; Rana, S.; Sheehan, M.; Kennedy, J.; Yelskaya, Z.; Rai, V.; Li, Y.; Yang, C.; Wong, D.; Rijo, I.; Casanova, J.; Somar, J.; Mehta, N.; Park, H.; Ostafi, S.; Arora, K.; Padunan, A.; Ewalt, M. D.; Aypar, U.; Terraf, P.; Misyura, M.; Haque, S.; Behr, G. G.; Haque, T.; Sulis, M.; Geyer, M. B.; Forlenza, C.; Thompson, M. C.; Carlo, M.; Latham, A.; Liu, Y.; Zehir, A.; Brannon, R.; Berger, M.; Diaz, L. A. Jr; Dogan, A.; Ladanyi, M.; Petrova-Drus, K.; Nafa, K.; Offit, K.; Arcila, M.; Stadler, Z. K.; Walsh, M. F.; Mandelker, D.
Title:	Universal germline genetic testing in patients with hematologic malignancies using DNA isolated from nail clippings
Keywords:	adolescent; adult; child; human tissue; aged; chronic myelomonocytic leukemia; major clinical study; single nucleotide polymorphism; somatic mutation; exon; gene deletion; genetics; validation process; prospective study; letter; polymerase chain reaction; cancer susceptibility; gene amplification; anemia; thrombocytopenia; gene frequency; pathology; chronic myeloid leukemia; risk factor; renal cell carcinoma; germ line; b cell lymphoma; hematologic malignancy; myelodysplastic syndrome; hematologic neoplasms; colonoscopy; mismatch repair; diagnosis; nail; nails; checkpoint kinase 2; idiopathic thrombocytopenic purpura; chronic lymphatic leukemia; genetic screening; lynch syndrome; protein msh6; mismatch repair protein pms2; germ-line mutation; genomic dna; genetic testing; myeloproliferative neoplasm; hematologic disease; penetrance; fanconi anemia; ataxia telangiectasia; transcription factor etv6; transcription factor runx1; dna isolation; copy number variation; germline mutation; acute myeloid leukemia; procedures; microchimerism; high throughput sequencing; dna sequencing; humans; human; male; female; butadiene diepoxide; neurofibromatosis type 3; nail clipping
Journal Title:	Haematologica
Volume:	109
Issue:	10
ISSN:	0390-6078
Publisher:	Ferrata Storti Foundation
Date Published:	2024-10-01
Start Page:	3383
End Page:	3390
Language:	English
DOI:	10.3324/haematol.2024.285055
PUBMED:	38572560
PROVIDER:	scopus
PMCID:	PMC11443390
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85205506351&doi=10.3324%2fhaematol.2024.285055&partnerID=40&md5=385f31639bdf0c121c5075e5846ebb23
Notes:	The MSK Cancer Center Support Grant (P30 CA008748) is acknowledge in the PDF -- Corresponding authors is MSK author: Diana Mandelker, Michael F. Walsh, Zsofia K. Stadler -- Source: Scopus