Synapse - Baseline MRI predictors of successful organ preservation in the Organ Preservation in Rectal Adenocarcinoma (OPRA) trial

Baseline MRI predictors of successful organ preservation in the Organ Preservation in Rectal Adenocarcinoma (OPRA) trial Journal Article

Authors:	Williams, H.; Yuval, J. B.; Verheij, F. S.; Miranda, J.; Lin, S. T.; Omer, D. M.; Qin, L. X.; Gollub, M. J.; Kim, T. H.; Garcia-Aguilar, J.; on behalf of the OPRA Consortium
Contributors:	Patil, S.; Kim, J. K.; Thompson, H. M.; Marco, M. R.; Lee, M.; Paty, P. B.; Weiser, M. R.; Nash, G. M.; Pappou, E.; Wei, I. H.; Widmar, M.; Segal, N. H.; Cercek, A.; Yaeger, R.; Smith, J. J.; Wu, A. J.; Saltz, L. B.
Article Title:	Baseline MRI predictors of successful organ preservation in the Organ Preservation in Rectal Adenocarcinoma (OPRA) trial
Abstract:	Background Prospective randomized trials have not yet identified baseline features predictive of organ preservation in locally advanced rectal cancers treated with total neoadjuvant therapy and a selective watch-and-wait strategy.Methods This was a secondary analysis of the OPRA trial, which randomized patients with stage II-III rectal adenocarcinoma to receive either induction or consolidation total neoadjuvant therapy. Patients were recommended for total mesorectal excision, or watch and wait based on clinical response at 8 +/- 4 weeks after completing treatment. Standardized baseline clinical and radiological variables were collected prospectively. Survival outcomes, including total mesorectal excision-free survival, disease-free survival, and overall survival, were assessed by intention-to-treat analysis. Cox proportional hazards models were used to evaluate associations between baseline variables and survival outcomes.Results Of the 324 patients randomized for the OPRA trial, 38 (11.7%) had cT4 tumours, 230 (71.0%) cN-positive disease, 101 (32.5%) mesorectal fascia involvement, and 64 (19.8%) extramural venous invasion. Several baseline features were independently associated with recommendation for total mesorectal excision on multivariable analysis: nodal disease (HR 1.66, 95% c.i. 1.12 to 2.48), extramural venous invasion (HR 1.57, 1.07 to 2.29), mesorectal fascia involvement (HR 1.45, 1.01 to 2.09), and tumour length (HR 1.11, 1.00 to 1.22). Of these, nodal disease (HR 2.02, 1.15 to 3.53) and mesorectal fascia involvement (HR 2.02, 1.26 to 3.26) also predicted worse disease-free survival. Age (HR 1.03, 1.00 to 1.06) was associated with overall survival.Conclusion Baseline MRI features, including nodal disease, extramural venous invasion, mesorectal fascia involvement, and tumour length, independently predict the likelihood of organ preservation after completion of total neoadjuvant therapy. Mesorectal fascia involvement and nodal disease are associated with disease-free survival. Prospective randomized studies have not yet evaluated baseline features that predict organ preservation in locally advanced rectal cancer treated with total neoadjuvant therapy and a selective watch-and-wait strategy. This secondary analysis of the OPRA trial demonstrated that baseline MRI features, including nodal status, extramural venous invasion, mesorectal fascia involvement, and tumour length, independently predict total mesorectal excision-free survival. Nodal status and mesorectal fascia involvement are associated with disease-free survival.
Keywords:	survival; adjuvant chemotherapy; neoadjuvant chemotherapy; chemoradiation; therapy; preoperative chemoradiotherapy; total mesorectal excision; tumor response; open-label; cancer
Journal Title:	British Journal of Surgery
Volume:	111
Issue:	9
ISSN:	0007-1323
Publisher:	Oxford University Press
Date Published:	2024-09-01
Start Page:	znae246
Language:	English
ACCESSION:	WOS:001319489700001
DOI:	10.1093/bjs/znae246
PROVIDER:	wos
PMCID:	PMC11422670
PUBMED:	39319400
Notes:	Article -- MSK Cancer Center Support Grant (P30 CA008748) acknowledged in PDF -- MSK corresponding author is Julio Garcia-Aguilar -- Source: Wos