Barrier films or dressings for the prevention of acute radiation dermatitis in breast cancer: A systematic review and network meta-analysis Review
| Authors: | Wong, H. C. Y.; Lee, S. F.; Caini, S.; Chan, A. W.; Kwan, J. Y. Y.; Waddle, M.; Sonis, S.; Herst, P.; Alcorn, S.; Bonomo, P.; Wong, C.; Corbin, K.; Choi, J. I.; Rembielak, A.; AlKhaifi, M.; Marta, G. N.; Rades, D.; van den Hurk, C.; Wolf, J. R.; Chan, R. J.; Schmeel, L. C.; Lock, M.; Hijal, T.; Cao, J.; Kim, H.; Chow, E. |
| Review Title: | Barrier films or dressings for the prevention of acute radiation dermatitis in breast cancer: A systematic review and network meta-analysis |
| Abstract: | Background: Barrier films or dressings were reported to be effective in preventing radiation dermatitis (RD) in breast cancer patients, but their comparative efficacy is unknown. Methods: A systematic literature search was performed on Embase, MEDLINE and Cochrane CENTRAL Registry of Clinical Trials from inception to October 20, 2023. Randomised controlled trials (RCTs) comparing barrier films or dressings to the standard of care (SOC) or other interventions were included. We estimated summary odds ratios and mean differences using network meta-analysis with random effects. This study was registered with PROSPERO (ID: CRD42023475021). Results: Fourteen RCTs met inclusion criteria. Six interventions were analysed: 3MTM Moisturizing Double Barrier Cream (MDBC), 3MTM No Sting Barrier Film (BF), Hydrofilm® (HF), Mepitel® Film (MF), Silver Leaf Nylon Dressing and StrataXRT®. HF, MF and StrataXRT® reduced the incidence of moist desquamation compared to SOC (HF: OR = 0.08; p = 0.02; MF: OR = 0.31 p < 0.01; StrataXRT®: OR = 0.22, p = 0.04). The ranking of agents from most to least effective in preventing moist desquamation according to P-scores was HF (92.5%), MF (78.5%), StrataXRT® (70.1%), BF (46.4%), Silver Leaf Nylon Dressing (24.9%), MDBC (22.9%) and SOC (14.7%). Only four RCTs on HF and MF included patient-reported outcome (PRO) assessments that allowed pooling for analysis. HF and MF were more effective in reducing pain, itchiness and burning sensation compared to SOC (p < 0.01 for all symptoms). Conclusion: HF and MF were effective in preventing RD in breast cancer. Future RCTs should compare these interventions to effective cream preparations, such as topical corticosteroids. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024. |
| Keywords: | treatment outcome; unclassified drug; review; area under the curve; cancer patient; edema; quality of life; pain; breast cancer; radiotherapy; randomized controlled trials as topic; breast neoplasms; pruritus; health care quality; maculopapular rash; intervention study; systematic review; breast tumor; polymerization; erythema; medline; hydrocortisone; cochrane library; corticosteroid; meta analysis; burning sensation; radiation dermatitis; skin redness; prevention and control; desquamation; embase; bandage; bandages; heterogeneity; etiology; randomized controlled trial (topic); urea; radiodermatitis; blister; glycerol; silicone; patient-reported outcome; mometasone furoate; humans; human; female; network meta-analysis; efficacy parameters; preferred reporting items for systematic reviews and meta-analyses; barrier dressings; barrier film; polyetherurethan; sorbolene; itchiness; photospectroscopy; radiation induced skin reaction assessment scale (; surface under the cumulative ranking curve |
| Journal Title: | Breast Cancer Research and Treatment |
| Volume: | 207 |
| Issue: | 3 |
| ISSN: | 0167-6806 |
| Publisher: | Springer |
| Date Published: | 2024-10-01 |
| Start Page: | 477 |
| End Page: | 496 |
| Language: | English |
| DOI: | 10.1007/s10549-024-07435-2 |
| PUBMED: | 39112742 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Source: Scopus |
