Vascular resection and reconstruction in recurrent granulosa cell tumor Journal Article
| Authors: | Finch, L.; Ellozy, S.; Sandhu, J.; Patel, T.; Tew, W. P.; Chi, D. S. |
| Article Title: | Vascular resection and reconstruction in recurrent granulosa cell tumor |
| Abstract: | Introduction: Oncovascular surgery is a rare but important component of radical surgery in gynecologic cancer, requiring interdisciplinary collaboration and coordination. In this case report, we review the case of a patient with recurrent granulosa cell tumor who underwent extensive oncovascular resection and reconstruction. Case presentation: Our patient was initially diagnosed with a stage IC granulosa cell tumor in 1989 following a left salpingo—oophorectomy secondary to ovarian cyst rupture. She subsequently had multiple recurrences requiring 8 surgical procedures from 1989 to 2022. Her most recent recurrence was notable for a 6 x 8 cm left pelvic tumor invading into the inferior vena cava (IVC), encasing the aorta, left common and external iliac vessels, and involving the left ureter. In a combined case with gynecologic surgery, vascular surgery, and urology, extensive oncovascular resection was performed, including an en bloc resection of the recurrent granulosa cell tumor, aorta, bilateral common and left external iliac arteries and veins, with aortal and IVC reconstruction. Despite a complicated postoperative course, she recovered well, received no further oncologic treatment, and remains on surveillance without evidence of disease 26 months later. Conclusion: To our knowledge, this is the first reported case of oncovascular surgery involving aortic and IVC resection and reconstruction for recurrent granulosa cell tumor. © 2024 The Authors |
| Keywords: | adult; cancer chemotherapy; clinical article; treatment response; antibiotic agent; cancer recurrence; case report; drug withdrawal; hypertension; paclitaxel; cancer radiotherapy; salpingooophorectomy; ovarian cancer; carboplatin; computer assisted tomography; smad3 protein; deep vein thrombosis; vascularization; postoperative complication; leuprorelin; hospitalization; karnofsky performance status; ciprofloxacin; granulosa cell tumor; interventional radiology; bacteremia; letrozole; osteoporosis; gentamicin; ca 125 antigen; anastrozole; drug substitution; inferior cava vein; levofloxacin; gynecologic surgery; tobramycin; abdominal hysterectomy; computed tomographic angiography; small intestine obstruction; small intestine resection; enoxaparin; piperacillin plus tazobactam; rivaroxaban; ovary cyst; inhibin; en bloc resection; pseudomonas aeruginosa; vagina bleeding; cefepime; fresh frozen plasma; ceftazidime; mixed lineage leukemia protein; vascular surgery; meropenem; imipenem; proctectomy; ureteroureterostomy; great blood vessel; human; female; article; side to side anastomosis; dual antiplatelet therapy; forkhead box protein l2; common iliac artery; oncovascular surgery; aortic graft; external iliac artery |
| Journal Title: | Gynecologic Oncology Reports |
| Volume: | 55 |
| ISSN: | 2352-5789 |
| Publisher: | Elsevier B.V. |
| Date Published: | 2024-09-30 |
| Start Page: | 101496 |
| Language: | English |
| DOI: | 10.1016/j.gore.2024.101496 |
| PROVIDER: | scopus |
| PMCID: | PMC11408049 |
| PUBMED: | 39297077 |
| DOI/URL: | |
| Notes: | Article -- MSK Cancer Center Support Grant (P30 CA008748) acknowledged in PDF -- MSK corresponding author is Dennis Chi -- Source: Scopus |
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