Comparisons of impact of vein grafting with different indications on outcomes of reconstruction with free flaps Journal Article


Authors: Coriddi, M.; Kim, L.; Haglich, K.; Nelson, J.; Shahzad, F.; Dayan, J.; Disa, J.; Mehrara, B.; Cordeiro, P.; McCarthy, C.
Article Title: Comparisons of impact of vein grafting with different indications on outcomes of reconstruction with free flaps
Abstract: Background Prior studies have shown an increased risk of complications and flap loss with the use of vein grafts in microsurgery. We hypothesize that indication for use of a vein graft can affect flap complications and loss rates. Methods We performed a retrospective review of all patients at our institution from 2010 to 2020 who underwent free flap reconstruction and required use of a vein graft. Indications for vein grafting included: salvage of flap during primary operation after microvascular compromise, augmentation of flow during primary operation, lengthening of the flap pedicle during the primary operation, and salvage of the flap during a secondary salvage operation after microvascular compromise. Results A total of 79 patients met the study inclusion criteria. There were significant differences among the vein graft indication groups and the following: area of reconstruction (p = 0.002), vein graft length (p = 0.018), vessels grafted (p = 0.001), vein graft donor site (p = 0.011), and total flap loss (p = 0.047). Of the four indications for vein grafting, salvage of the flap during secondary salvage operation after microvascular compromise had the highest rate of total flap loss (26.7%). There were no significant associations between other flap complications and vein graft indications. Conclusion Vein graft use in the primary reconstructive setting is efficacious, with low risk of thrombosis. Use in secondary procedures, however, is associated with higher rates of total flap loss, likely due to the thrombotic process, which was initiated prior to the use of the graft resulting in the salvage procedure and not secondary to the graft itself. © 2024. Thieme. All rights reserved. Thieme Medical Publishers, Inc.
Keywords: adult; controlled study; treatment outcome; aged; middle aged; retrospective studies; major clinical study; donor site; plastic surgery; salvage therapy; comparative study; cohort analysis; microsurgery; transplantation; vascularization; retrospective study; postoperative complication; postoperative complications; surgery; graft survival; free tissue graft; pedicled skin flap; veins; demographics; vein; free tissue flaps; procedures; vein graft; microvascular reconstruction; humans; human; male; female; article; plastic surgery procedures
Journal Title: Journal of Reconstructive Microsurgery
Volume: 40
Issue: 7
ISSN: 0743-684X
Publisher: Thieme Medical Publishers, Inc.  
Date Published: 2024-09-01
Start Page: 535
End Page: 541
Language: English
DOI: 10.1055/a-2240-1534
PUBMED: 38190987
PROVIDER: scopus
DOI/URL:
Notes: The MSK Cancer Center Support Grant (P30 CA008748) is acknowledge in PubMed and PDF -- Corresponding authors is MSK author: Michelle Coriddi -- Source: Scopus
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MSK Authors
  1. Joseph Disa
    265 Disa
  2. Babak Mehrara
    454 Mehrara
  3. Peter G Cordeiro
    288 Cordeiro
  4. Colleen Marie McCarthy
    144 McCarthy
  5. Joseph Henry Dayan
    101 Dayan
  6. Jonas Allan Nelson
    217 Nelson
  7. Michelle Renee Coriddi
    62 Coriddi
  8. Farooq Shahzad
    38 Shahzad
  9. Leslie Narae Kim
    12 Kim
  10. Kathryn Ann Haglich
    27 Haglich