Molecular image–guided surgery in gynaecological cancer: Where do we stand? Review
| Authors: | Pisano, G.; Wendler, T.; Valdés Olmos, R. A.; Garganese, G.; Rietbergen, D. D. D.; Giammarile, F.; Vidal-Sicart, S.; Oonk, M. H. M.; Frumovitz, M.; Abu-Rustum, N. R.; Scambia, G.; Rufini, V.; Collarino, A. |
| Review Title: | Molecular image–guided surgery in gynaecological cancer: Where do we stand? |
| Abstract: | Purpose: The aim of this review is to give an overview of the current status of molecular image–guided surgery in gynaecological malignancies, from both clinical and technological points of view. Methods: A narrative approach was taken to describe the relevant literature, focusing on clinical applications of molecular image–guided surgery in gynaecology, preoperative imaging as surgical roadmap, and intraoperative devices. Results: The most common clinical application in gynaecology is sentinel node biopsy (SNB). Other promising approaches are receptor-target modalities and occult lesion localisation. Preoperative SPECT/CT and PET/CT permit a roadmap for adequate surgical planning. Intraoperative detection modalities span from 1D probes to 2D portable cameras and 3D freehand imaging. Conclusion: After successful application of radio-guided SNB and SPECT, innovation is leaning towards hybrid modalities, such as hybrid tracer and fusion of imaging approaches including SPECT/CT and PET/CT. Robotic surgery, as well as augmented reality and virtual reality techniques, is leading to application of these innovative technologies to the clinical setting, guiding surgeons towards a precise, personalised, and minimally invasive approach. © The Author(s) 2024. |
| Keywords: | review; cancer localization; treatment planning; nuclear magnetic resonance imaging; methylene blue; endometrium cancer; sentinel lymph node biopsy; ovary cancer; molecular imaging; diagnostic imaging; biopsy; genital neoplasms, female; preoperative period; intraoperative period; uterine cervix cancer; surgery; tracer; diseases; fluorescence imaging; female genital tract tumor; clinical application; intra-operative; surgery, computer-assisted; current status; randomized controlled trial (topic); occult cancer; phase 2 clinical trial (topic); meta analysis (topic); phase 3 clinical trial (topic); vulva cancer; female genital tract cancer; spect/ct; sentinel node biopsy; robotic surgery; multicenter study (topic); virtual reality; image-guided surgery; image guided surgery; computer assisted surgery; procedures; hybrid; systematic review (topic); transplantation (surgical); gynecological cancer; three-dimensional imaging; humans; human; female; positron emission tomography-computed tomography; roadmap; single photon emission computed tomography-computed tomography; two-dimensional imaging; augmented reality; robotics surgery; gynaecological cancers; hybrid tracer; sentinel node biopsies; biotechnological procedures; molecular image guided surgery |
| Journal Title: | European Journal of Nuclear Medicine and Molecular Imaging |
| Volume: | 51 |
| Issue: | 10 |
| ISSN: | 1619-7070 |
| Publisher: | Springer |
| Date Published: | 2024-08-01 |
| Start Page: | 3026 |
| End Page: | 3039 |
| Language: | English |
| DOI: | 10.1007/s00259-024-06604-1 |
| PUBMED: | 38233609 |
| PROVIDER: | scopus |
| PMCID: | PMC11300493 |
| DOI/URL: | |
| Notes: | Review -- MSK Cancer Center Support Grant (P30 CA008748) acknowledged in PDF -- Source: Scopus |
