Hypomethylating agents are associated with high rates of hematologic toxicity in patients with secondary myeloid neoplasms developing after acquired aplastic anemia Research Letter


Authors: Connor, M. P.; Prathapa, N.; Frey, N. V.; Gill, S. I.; Hexner, E. O.; Bruno, X. J.; Lai, C. E.; Loren, A. W.; Luger, S. M.; Matthews, A. H.; McCurdy, S. R.; Perl, A. E.; Porter, D. L.; Zeringue, A.; Oved, J. H.; Olson, T. S.; Pratz, K. W.; Babushok, D. V.
Title: Hypomethylating agents are associated with high rates of hematologic toxicity in patients with secondary myeloid neoplasms developing after acquired aplastic anemia
Keywords: adult; child; clinical article; controlled study; preschool child; school child; aged; aged, 80 and over; middle aged; unclassified drug; gene mutation; overall survival; allogeneic stem cell transplantation; neutropenia; hepatitis; outcome assessment; antineoplastic agent; letter; infection; antimetabolites, antineoplastic; blood toxicity; thrombocytopenia; clinical assessment; cohort analysis; drug effect; dna methylation; febrile neutropenia; hospitalization; graft failure; hematologic malignancy; myelodysplastic syndrome; death; tumor protein; hospital admission; hematopoietic stem cell; neoplasms, second primary; drug therapy; immunosuppressive treatment; antineoplastic antimetabolite; cytopenia; brain hemorrhage; cyclosporine; azacitidine; myelodysplastic syndromes; paroxysmal nocturnal hemoglobinuria; thymocyte antibody; aplastic anemia; dysplasia; transcription factor runx1; dna methyltransferase 3a; etiology; acute myeloid leukemia; anemia, aplastic; clonal hematopoiesis; Common Terminology Criteria for Adverse Events; hypomethylating agent; international prognostic scoring system; asxl1 protein; disease burden; very elderly; humans; human; male; female; venetoclax; clonal hematopoiesis of indeterminate potential; alloimmunization; second primary neoplasm; acquired aplastic anemia; secondary myeloid neoplasm
Journal Title: Haematologica
Volume: 109
Issue: 8
ISSN: 0390-6078
Publisher: Ferrata Storti Foundation  
Date Published: 2024-08-01
Start Page: 2732
End Page: 2737
Language: English
DOI: 10.3324/haematol.2024.285275
PUBMED: 38634143
PROVIDER: scopus
PMCID: PMC11290501
DOI/URL:
Notes: Letter -- Source: Scopus
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  1. Joseph Hai Oved
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