Synapse - Colonic adenosquamous carcinoma: A single-center review of patient clinicopathologic characteristics, genetics, and clinical outcomes

Colonic adenosquamous carcinoma: A single-center review of patient clinicopathologic characteristics, genetics, and clinical outcomes Journal Article

Authors:	Lieb, D. A. 2nd; Thompson, H. M.; Verheij, F. S.; Shia, J.; Sanchez-Vega, F.; Karagkounis, G.; Widmar, M.; Wei, I. H.; Smith, J. J.; Nash, G. M.; Weiser, M. R.; Paty, P. B.; Cercek, A.; Saltz, L. B.; Garcia-Aguilar, J.; Pappou, E.
Article Title:	Colonic adenosquamous carcinoma: A single-center review of patient clinicopathologic characteristics, genetics, and clinical outcomes
Abstract:	(1) Background: Adenosquamous carcinoma (ASC) is a rare subtype of colon cancer. Its rarity makes characterization challenging, although colonic ASC is believed to present at more advanced stages and have worse outcomes versus adenocarcinoma. This study aims to characterize the clinicopathological characteristics and clinical outcomes of colonic ASC. (2) Methods: This is a single-center, retrospective review of patients diagnosed with colonic ASC from 2000 to 2020. Data extracted included patient demographics, staging at diagnosis, tumor clinicopathologic and genetic characteristics, and clinical outcomes. (3) Results: Among 61,126 patients with colorectal cancer, 13 (0.02%) had colonic ASC, with a mean age at diagnosis of 48.7 years. The cecum/ascending colon was the most common primary site (6/13, 46.2%), and all except one patient was diagnosed with Stage III or IV disease. Among the eight patients with mismatch repair genetics available, only one was mismatch repair deficient. Eleven patients (84.6%) underwent surgery, and 11 likewise received some form of chemotherapy. Recurrence occurred in 7 of 13 patients (53.8%), and the overall five-year survival rate was 38.5%. The median survival rate was 39.4 months overall (30.5 months for Stage III, 23.7 months for Stage IV). (4) Conclusions: Overall, colonic ASC is rare, and this cohort of colonic ASC patients demonstrated advanced stage at diagnosis, frequent recurrence, and poor overall survival. Additional research remains to compare these characteristics with those of comparably staged adenocarcinoma and to develop specific management recommendations. © 2024 by the authors.
Keywords:	immunohistochemistry; adult; middle aged; survival rate; overall survival; genetics; mortality; chemotherapy; follow up; colorectal cancer; cohort analysis; cell differentiation; histology; tumor suppressor gene; folinic acid; colon cancer; mismatch repair; recurrent disease; adenosquamous carcinoma; neoadjuvant chemotherapy; oxaliplatin; colon adenocarcinoma; cecum; rectum anterior resection; clinical outcome; adenosquamous; ascending colon; transverse colon; human; male; female; article; whole exome sequencing; splenic flexure; adenosquamous colon cancer; subtotal colectomy
Journal Title:	Cancers
Volume:	16
Issue:	15
ISSN:	2072-6694
Publisher:	MDPI
Date Published:	2024-08-01
Start Page:	2641
Language:	English
DOI:	10.3390/cancers16152641
PROVIDER:	scopus
PMCID:	PMC11311507
PUBMED:	39123369
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85201011323&doi=10.3390%2fcancers16152641&partnerID=40&md5=de29272cea3079b55fdec33a07d633cb
Notes:	Article -- MSK Cancer Center Support Grant (P30 CA008748) acknowledged in PubMed and PDF -- MSK corresponding author is Emmanouil Pappou -- Source: Scopus