Distinct developmental pathways generate functionally distinct populations of natural killer cells Journal Article
| Authors: | Ding, Y.; Lavaert, M.; Grassmann, S.; Band, V. I.; Chi, L.; Das, A.; Das, S.; Harly, C.; Shissler, S. C.; Malin, J.; Peng, D.; Zhao, Y.; Zhu, J.; Belkaid, Y.; Sun, J. C.; Bhandoola, A. |
| Article Title: | Distinct developmental pathways generate functionally distinct populations of natural killer cells |
| Abstract: | Natural killer (NK) cells function by eliminating virus-infected or tumor cells. Here we identified an NK-lineage-biased progenitor population, referred to as early NK progenitors (ENKPs), which developed into NK cells independently of common precursors for innate lymphoid cells (ILCPs). ENKP-derived NK cells (ENKP_NK cells) and ILCP-derived NK cells (ILCP_NK cells) were transcriptionally different. We devised combinations of surface markers that identified highly enriched ENKP_NK and ILCP_NK cell populations in wild-type mice. Furthermore, Ly49H+ NK cells that responded to mouse cytomegalovirus infection primarily developed from ENKPs, whereas ILCP_NK cells were better IFNγ producers after infection with Salmonella and herpes simplex virus. Human CD56dim and CD56bright NK cells were transcriptionally similar to ENKP_NK cells and ILCP_NK cells, respectively. Our findings establish the existence of two pathways of NK cell development that generate functionally distinct NK cell subsets in mice and further suggest these pathways may be conserved in humans. © This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2024. |
| Keywords: | controlled study; human cell; nonhuman; flow cytometry; cd3 antigen; animal cell; mouse; animal; cytology; metabolism; animals; mice; mice, knockout; animal tissue; cells, cultured; stem cell factor; transcription factor gata 3; embryo; animal experiment; animal model; cell differentiation; mice, inbred c57bl; cell lineage; c57bl mouse; salmonellosis; immunology; gamma interferon; cell culture; natural killer cell; killer cells, natural; innate immunity; immunity, innate; interferon-gamma; transcription factor t bet; lymphoid progenitor cell; precursor; herpes simplex virus; cytomegalovirus infection; chemokine receptor ccr2; cd19 antigen; knockout mouse; cd27 antigen; interleukin 2 receptor alpha; cd135 antigen; salmonella; cd56 antigen; eomesodermin; interleukin 2 receptor beta; lymphoid progenitor cells; innate lymphoid cell; muromegalovirus; humans; human; article; transcription factor 7 like 1; single cell rna seq |
| Journal Title: | Nature Immunology |
| Volume: | 25 |
| Issue: | 7 |
| ISSN: | 1529-2908 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2024-07-01 |
| Start Page: | 1183 |
| End Page: | 1192 |
| Language: | English |
| DOI: | 10.1038/s41590-024-01865-2 |
| PUBMED: | 38872000 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Erratum issued, see DOI: 10.1038/s41590-024-01917-7 -- Source: Scopus |
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