Development and validation of an automated computational approach to grade immune effector cell-associated hematotoxicity Journal Article

   

Authors:	Liang, E. C.; Rejeski, K.; Fei, T.; Albittar, A.; Huang, J. J.; Portuguese, A. J.; Wu, Q.; Raj, S.; Subklewe, M.; Shouval, R.; Gauthier, J.
Article Title:	Development and validation of an automated computational approach to grade immune effector cell-associated hematotoxicity
Abstract:	Hematologic toxicity frequently complicates chimeric antigen receptor (CAR) T-cell therapy, resulting in significant morbidity and mortality. In an effort to standardize reporting, the European Hematology Association (EHA) and European Society of Blood and Marrow Transplantation (EBMT) devised the immune effector cell-associated hematotoxicity (ICAHT) grading system, distinguishing between early (day 0-30) and late (after day +30) events based on neutropenia depth and duration. However, manual implementation of ICAHT grading criteria is time-consuming and susceptible to subjectivity and error. To address these challenges, we introduce a novel computational approach, utilizing the R programming language, to automate early and late ICAHT grading. Given the complexities of early ICAHT grading, we benchmarked our approach both manually and computationally in two independent cohorts totaling 1251 patients. Our computational approach offers significant implications by streamlining grading processes, reducing manual time and effort, and promoting standardization across varied clinical settings. We provide this tool to the scientific community alongside a comprehensive implementation guide, fostering its widespread adoption and enhancing reporting consistency for ICAHT. © The Author(s), under exclusive licence to Springer Nature Limited 2024.
Keywords:	mortality; neutropenia; follow up; neutrophil count; blood toxicity; morbidity; exercise; computer language; algorithm; chimeric antigen receptor; cell therapy; effector cell; computer model; erythrocyte transfusion; adoptive immunotherapy; immunotherapy, adoptive; tachycardia; lymphocyte count; adverse event; procedures; humans; human; male; female; article; chimeric antigen receptor t-cell immunotherapy
Journal Title:	Bone Marrow Transplantation
Volume:	59
Issue:	7
ISSN:	0268-3369
Publisher:	Nature Publishing Group
Date Published:	2024-07-01
Start Page:	910
End Page:	917
Language:	English
DOI:	10.1038/s41409-024-02278-3
PUBMED:	38627450
PROVIDER:	scopus
PMCID:	PMC11380036
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85190531084&doi=10.1038%2fs41409-024-02278-3&partnerID=40&md5=a0a0e08d92b1f7075c3a577b006724a9
Notes:	The MSK Cancer Center Support Grant (P30 CA008748) is acknowledge in the PDF -- Erratum published at DOI: 10.1038/s41409-024-02453-6 -- Source: Scopus

https://synapse.mskcc.org/synapse/works/has_related_data_chk/217624