Evaluation of a mobile behavior change program for weight loss in breast cancer survivors Journal Article
| Authors: | Shen, S.; Salehi, E.; White, C.; Chen, Y.; Iyengar, N. M. |
| Article Title: | Evaluation of a mobile behavior change program for weight loss in breast cancer survivors |
| Abstract: | Post-diagnosis weight gain is common in early-stage breast cancer and is associated with increased risk of recurrence and mortality. Intentional weight loss is difficult to maintain, and digital lifestyle interventions may provide a scalable approach to address this challenge. In this prospective single-arm study (ClinicalTrials.gov NCT04753268; February 15, 2021), key eligibility criteria included: stage I–III breast cancer, body mass index (BMI) ≥ 27.5 kg/m2, and completion of cancer treatment ≥6 months before study enrollment. Participants were provided with a behavioral change mobile application (Noom®). The primary endpoint was a change in self-reported weight from baseline to 26 weeks. Secondary endpoints included engagement, changes in physical activity, dietary patterns, and patient-reported outcomes (PRO). In total, 31 patients were enrolled (mean age 56.8 ± 9.9, mean baseline BMI 33.5 kg/m2 ± 6.5). The mean weight change was −4.8 kg (± 4.4, P < 0.001), mean percent weight change was −5.6% (± 5.0%); 11/31 patients (35.5%) lost ≥5% of their initial weight. Metrics of digital application engagement associated with weight loss ≥5% included articles read (P = 0.012), weights logged (P = 0.006), food records logged (P = 0.001), messages sent (P = 0.001), and application open count (P = 0.014). Significant increases were seen in mean daily step count (P = 0.004), GPAQ scores (P = 0.002), and Body Image Scale scores (P < 0.001). Mean energy intake remained consistently in a calorie-restricted range of 1300–1400 kcal/day. In this study, breast cancer survivors were highly engaged with a behavioral change smartphone application which led to clinically significant weight loss, increased physical activity, maintenance of an energy-restricted diet, and improvements in body image. © The Author(s) 2024. |
| Keywords: | adult; clinical article; controlled study; middle aged; clinical trial; mortality; caloric intake; breast cancer; mastectomy; cancer survivor; body mass; physical activity; diet restriction; body image; lumpectomy; lifestyle; behavior change; patient-reported outcome; body weight loss; dietary pattern; human; female; article; step count; body image scale; body weight change |
| Journal Title: | npj Breast Cancer |
| Volume: | 10 |
| ISSN: | 2374-4677 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2024-06-29 |
| Start Page: | 53 |
| Language: | English |
| DOI: | 10.1038/s41523-024-00659-x |
| PROVIDER: | scopus |
| PMCID: | PMC11217495 |
| PUBMED: | 38951532 |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledge in the PDF -- Corresponding authors is MSK author: Neil M. Iyengar -- Source: Scopus |
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