Lighting the torch: intratumoural T cell-to-stroma enrichment score as a predictor of immunotherapy response in urothelial carcinoma Editorial
| Authors: | Aggen, D. H.; Rosenberg, J. E. |
| Title: | Lighting the torch: intratumoural T cell-to-stroma enrichment score as a predictor of immunotherapy response in urothelial carcinoma |
| Abstract: | T cell infiltration in the tumour microenvironment (TME) is a prerequisite for sustained antitumour immune responses. However, identifying predictive biomarkers that quantify T cell infiltration and the presence of proinflammatory TMEs associated with immune-checkpoint inhibitor (ICI) response for clinical implementation has proved challenging. Here, we highlight a study that validates a T cell-to-stroma enrichment score generated from RNA sequencing data as a novel biomarker for ICI response in patients with urothelial carcinoma. © Springer Nature Limited 2024. |
| Keywords: | protein expression; treatment response; overall survival; cisplatin; placebo; adjuvant therapy; disease free survival; t lymphocyte; biological marker; progression free survival; gene expression profiling; cancer research; prediction; rna; immune response; quantitative analysis; scoring system; lymphocytic infiltration; stroma cell; transitional cell carcinoma; programmed death 1 ligand 1; programmed death 1 receptor; tumor microenvironment; immune checkpoint inhibitor; cancer prognosis; xeroderma pigmentosum group d protein; nivolumab; human; article; rna sequencing; pembrolizumab; cxcl13 chemokine; apolipoprotein b mrna editing enzyme catalytic polypeptide like; tumor mutational burden; enfortumab vedotin |
| Journal Title: | Nature Reviews Clinical Oncology |
| Volume: | 21 |
| Issue: | 7 |
| ISSN: | 1759-4774 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2024-07-01 |
| Start Page: | 487 |
| End Page: | 488 |
| Language: | English |
| DOI: | 10.1038/s41571-024-00890-2 |
| PUBMED: | 38622410 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Source: Scopus |
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