New strategies for locally advanced breast cancer: A Review of inflammatory breast cancer and nonresponders Review


Authors: Malhotra, S.; Tadros, A. B.
Review Title: New strategies for locally advanced breast cancer: A Review of inflammatory breast cancer and nonresponders
Abstract: This review explores the new strategies around the management of locally advanced breast cancer (LABC), particularly for nonresponsive tumors and/or initially unresectable tumors at diagnosis, inclusive of inflammatory breast cancer. Nonresponders to neoadjuvant systemic therapy present a unique clinical challenge. Emerging medical therapeutics as well as considerations for use of radiotherapy and/or surgery in this setting are discussed. Specifically, the use of neoadjuvant radiotherapy for LABC and lymphedema prevention with lymphatic reconstruction following axillary lymph node dissection are reviewed. © 2024 Elsevier Inc.
Keywords: cancer surgery; review; systemic therapy; cancer radiotherapy; neoadjuvant therapy; antineoplastic agent; lymph node dissection; lymph node excision; mastectomy; radiotherapy; pathology; breast neoplasms; breast tumor; inoperable cancer; breast surgery; therapy; axillary lymph node dissection; inflammatory breast cancer; procedures; advanced breast cancer; humans; human; female; breast cancer-related lymphedema; neoadjuvant systemic therapy; sacituzumab govitecan; lymphatic reconstruction; inflammatory breast neoplasms
Journal Title: Clinical Breast Cancer
Volume: 24
Issue: 4
ISSN: 1526-8209
Publisher: Elsevier Inc.  
Date Published: 2024-06-01
Start Page: 301
End Page: 309
Language: English
DOI: 10.1016/j.clbc.2024.01.009
PUBMED: 38431513
PROVIDER: scopus
DOI/URL:
Notes: Review -- Source: Scopus
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  1. Audree Blythe Tadros
    116 Tadros