Clinical evaluation and treatment in men with low testosterone levels and prostate cancer Review

   


Authors: Ljubetic, B. M.; Parada, F.; Flores, J. M.
Review Title: Clinical evaluation and treatment in men with low testosterone levels and prostate cancer
Abstract: Introduction: A high prevalence of low testosterone levels has been reported in men with prostate cancer. The use of testosterone therapy in men with a history of prostate cancer is still controversial, and there is uncertainty regarding the management of these patients. Methods: We analyzed the European and American guidelines on this topic and presented the clinical experience in the management of patients with low testosterone levels and a history of prostate cancer in one of the world's leading cancer centers. Results: According to the published evidence to date, testosterone therapy in men with prostate cancer does not increase the risk of prostate cancer recurrence in the short and medium term, but there is a lack of data on the long term. Symptomatic men with low testosterone levels who are candidates for this therapy need a thorough clinical evaluation before commencing testosterone therapy. Evaluation of prostate cancer history including type of treatment administered, pathologic stage of prostate cancer and prostate specific antigen should be requested before and during testosterone treatment to assess its trend. Conclusion: Prostate-specific antigen should remain undetectable after radical prostatectomy or stable after radiotherapy. Otherwise, it would be a sign of uncontrolled prostate cancer, and the patient may require cessation of testosterone therapy and referral to oncology for further evaluation. © 2023 AEU
Keywords: prostate cancer; testosterone therapy; testosterone deficiency; low testosterone
Journal Title: Actas Urológicas Españolas
Volume: 48
Issue: 6
ISSN: 0210-4806
Publisher: Elsevier Inc.  
Date Published: 2024-07-01
Start Page: 410
End Page: 415
Language: English; Spanish
DOI: 10.1016/j.acuroe.2023.12.001
PROVIDER: scopus
PMCID: PMC11169089
PUBMED: 38101513
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85183388946&doi=10.1016%2fj.acuro.2023.09.005&partnerID=40&md5=15f3991f3add9dc40b6e67c608ffb940
Notes: The MSK Cancer Center Support Grant (P30 CA008748) is acknowledge in the PDF -- Corresponding authors is MSK author: J.M. Flores -- "Evaluación clínica y tratamiento en hombres con testosterona baja y cáncer de próstata" -- Spanish edition DOI: 10.1016/j.acuro.2023.09.005 -- Source: Scopus
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  1. Jose Miguel Flores Martinez
    66 Flores Martinez
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