Bladder cancer survivors who do not smoke have better longitudinal health-related quality of life measures: An assessment of the Comparative Effectiveness and Survivorship Health in Bladder Cancer (CEASE-BC) study Journal Article
| Authors: | Kay, H.; Silver, S. N.; Smith, A. B.; Basak, R.; Shoenbill, K.; Usinger, D.; Goldstein, A. O.; Matulewicz, R. S.; Chen, R.; Bjurlin, M. A. |
| Article Title: | Bladder cancer survivors who do not smoke have better longitudinal health-related quality of life measures: An assessment of the Comparative Effectiveness and Survivorship Health in Bladder Cancer (CEASE-BC) study |
| Abstract: | Purpose:Cigarette smoking is the most common risk factor for the development of bladder cancer (BC), yet there is a paucity of data characterizing the relationship between smoking status and longitudinal health-related quality of life (HRQoL) outcomes in patients with BC. We examined the association between smoking status and HRQoL among patients with BC.Materials and Methods:Data were sourced from a prospective, longitudinal study open between 2014 and 2017, which examined HRQoL in patients aged ≥ 18 years old diagnosed with BC across North Carolina. The QLQ-C30 (European Organization for Research and Treatment of Cancer Quality of Life Questionnaire core instrument) was administered at 3, 12, and 24 months after BC diagnosis. Our primary exposure of interest was current smoking status. Linear regression using generalized estimating equations was used to analyze the relationship between smoking status and various domains of the QLQ-C30.Results:A total of 154 patients enrolled in the study. Eighteen percent were classified as smoking at 3 months from diagnosis, and packs per day ranged from < 0.5 to 2. When controlling for time from diagnosis, demographic covariates, cancer stage, and treatment type, mean differences for physical function (7.4), emotional function (5.6), and fatigue measures (-8.2) were significantly better for patients with BC who did not smoke.Conclusions:Patients with BC who do not smoke have significantly better HRQoL scores in the domains of physical function, emotional function, and fatigue. These results underscore the need to treat smoking as an essential component of BC care. © 2024 by AMERICAN UROLOGICAL ASSOCIATION EDUCATION AND RESEARCH, INC. |
| Keywords: | adult; cancer chemotherapy; controlled study; treatment outcome; aged; middle aged; cancer surgery; major clinical study; constipation; fatigue; diarrhea; cancer patient; cancer radiotherapy; cancer staging; follow up; antineoplastic agent; prospective study; prospective studies; bcg vaccine; quality of life; pain; cohort analysis; psychology; smoking cessation; smoking; bladder cancer; bladder tumor; urinary bladder neoplasms; cancer survivor; dyspnea; social status; questionnaire; insomnia; longitudinal studies; radical cystectomy; survivorship; cognition; nausea and vomiting; epidemiology; tobacco; african american; caucasian; longitudinal study; hispanic; american indian; pacific islander; cancer survivors; refusal to participate; global health; adverse event; comparative effectiveness; demographics; patient-reported outcome; partial cystectomy; non-smoker; transurethral resection of the bladder; humans; human; male; female; article; loss of appetite; surveys and questionnaires; european organization for research and treatment of cancer quality of life questionnaire core 30; current smoker; financial stress; non-smokers |
| Journal Title: | Journal of Urology |
| Volume: | 212 |
| Issue: | 1 |
| ISSN: | 0022-5347 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2024-07-01 |
| Start Page: | 87 |
| End Page: | 94 |
| Language: | English |
| DOI: | 10.1097/ju.0000000000003964 |
| PUBMED: | 38603576 |
| PROVIDER: | scopus |
| PMCID: | PMC11193885 |
| DOI/URL: | |
| Notes: | Article -- MSK Cancer Center Support Grant (P30 CA008748) acknowledged in PubMed -- Source: Scopus |
