Association between autoimmune diseases and monoclonal gammopathy of undetermined significance: An analysis from a population-based screening study Journal Article
| Authors: | Sverrisdottir, I.; Thorsteinsdottir, S.; Rognvaldsson, S.; Aspelund, T.; Vidarsson, B.; Onundarson, P. T.; Agnarsson, B. A.; Sigurdardottir, M.; Thorsteinsdóttir, I.; Sveinsdottir, S. V.; Palmason, R.; Olafsson, I.; Sigurdsson, F.; Thordardóttir, A. R.; Eythorsson, E.; Jonsson, A.; Palsson, R.; Indridason, O. S.; Gislason, G. K.; Olafsson, A.; Sigurdsson, J.; Steingrímsdóttir, H.; Long, T. E.; Hultcrantz, M.; Durie, B. G. M.; Harding, S.; Landgren, O.; Kristinsson, S. Y.; Love, T. J. |
| Article Title: | Association between autoimmune diseases and monoclonal gammopathy of undetermined significance: An analysis from a population-based screening study |
| Abstract: | Background: Monoclonal gammopathy of undetermined significance (MGUS) is a precursor of multiple myeloma (MM) and related conditions. In previous registry-based, retrospective studies, autoimmune diseases have been associated with MGUS. However, these studies were not based on a screened population and are therefore prone to ascertainment bias. Objective: To examine whether MGUS is associated with autoimmune diseases. Design: A cross-sectional study within iStopMM (Iceland Screens, Treats, or Prevents MM), a prospective, population-based screening study of MGUS. Setting: Icelandic population of adults aged 40 years or older. Patients: 75 422 persons screened for MGUS. Measurements: Poisson regression for prevalence ratios (PRs) of MGUS among persons with or without an autoimmune disease, adjusted for age and sex. Results: A total of 10 818 participants had an autoimmune disorder, of whom 599 had MGUS (61 with a prior clinical diagnosis and 538 diagnosed at study screening or evaluation). A diagnosis of an autoimmune disease was not associated with MGUS (PR, 1.05 [95% CI, 0.97 to 1.15]). However, autoimmune disease diagnoses were associated with a prior clinical diagnosis of MGUS (PR, 2.11 [CI, 1.64 to 2.70]). Limitation: Registry data were used to gather information on autoimmune diseases, and the homogeneity of the Icelandic population may limit the generalizability of these results. Conclusion: The study did not find an association between autoimmune disease and MGUS in a systematically screened population. Previous studies not done in systematically screened populations have likely been subject to ascertainment bias. The findings indicate that recommendations to routinely screen patients with autoimmune disease for MGUS may not be warranted. © 2024 American College of Physicians. All rights reserved. |
| Keywords: | adult; controlled study; aged; middle aged; major clinical study; prospective study; prospective studies; disease association; randomized controlled trial; prevalence; cohort analysis; mass screening; retrospective study; diagnosis; medical record; cross-sectional study; cross-sectional studies; sex difference; autoimmune hemolytic anemia; idiopathic thrombocytopenic purpura; rheumatoid arthritis; systemic lupus erythematosus; ulcerative colitis; epidemiology; myasthenia gravis; autoimmune diseases; autoimmune disease; insulin dependent diabetes mellitus; multiple sclerosis; non-hodgkin lymphoma; complication; autoimmune hepatitis; iceland; hashimoto disease; guillain barre syndrome; celiac disease; pernicious anemia; graves disease; procedures; motor neuron disease; discoid lupus erythematosus; polyarteritis nodosa; systemic sclerosis; social media; humans; human; male; female; article; wegener granulomatosis; psoriatic arthritis; monoclonal gammopathy of undetermined significance; dressler syndrome; poisson regression; addison disease; prevalence ratio; ascertainment bias; localized scleroderma; mixed connective tissue disease; reactive arthritis; rheumatic fever |
| Journal Title: | Annals of Internal Medicine |
| Volume: | 177 |
| Issue: | 6 |
| ISSN: | 0003-4819 |
| Publisher: | American College of Physicians |
| Date Published: | 2024-06-01 |
| Start Page: | 711 |
| End Page: | 718 |
| Language: | English |
| DOI: | 10.7326/m23-2867 |
| PUBMED: | 38768457 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PDF -- Source: Scopus |
