Sex differences orchestrated by androgens at single-cell resolution Journal Article
| Authors: | Li, F.; Xing, X.; Jin, Q.; Wang, X. M.; Dai, P.; Han, M.; Shi, H.; Zhang, Z.; Shao, X.; Peng, Y.; Zhu, Y.; Xu, J.; Li, D.; Chen, Y.; Wu, W.; Wang, Q.; Yu, C.; Chen, L.; Bai, F.; Gao, D. |
| Article Title: | Sex differences orchestrated by androgens at single-cell resolution |
| Abstract: | Sex differences in mammalian complex traits are prevalent and are intimately associated with androgens1–7. However, a molecular and cellular profile of sex differences and their modulation by androgens is still lacking. Here we constructed a high-dimensional single-cell transcriptomic atlas comprising over 2.3 million cells from 17 tissues in Mus musculus and explored the effects of sex and androgens on the molecular programs and cellular populations. In particular, we found that sex-biased immune gene expression and immune cell populations, such as group 2 innate lymphoid cells, were modulated by androgens. Integration with the UK Biobank dataset revealed potential cellular targets and risk gene enrichment in antigen presentation for sex-biased diseases. This study lays the groundwork for understanding the sex differences orchestrated by androgens and provides important evidence for targeting the androgen pathway as a broad therapeutic strategy for sex-biased diseases. © The Author(s), under exclusive licence to Springer Nature Limited 2024. |
| Keywords: | immunohistochemistry; signal transduction; androgen; nonhuman; flow cytometry; mass spectrometry; peroxidase; mouse; animal; cytology; metabolism; animals; mice; gene expression; ovariectomy; animal experiment; immunofluorescence; drug effect; mice, inbred c57bl; c57bl mouse; mus musculus; antigen presentation; immunology; antigen; tamoxifen; innate immunity; immunity, innate; sex difference; real time polymerase chain reaction; androgen deprivation therapy; lymphocyte; lymphocytes; fluorescence activated cell sorting; transcriptome; united kingdom; androgens; cd19 antigen; neutrophil chemotaxis; rna extraction; immunochemistry; rna sequence; sex characteristics; single cell analysis; single-cell analysis; gastritis; liquid chromatography-mass spectrometry; corticosterone; cell component; humans; human; male; female; article; differential gene expression; duodenitis; biobank; single cell rna seq; sexual characteristics; group 2 innate lymphoid cell |
| Journal Title: | Nature |
| Volume: | 629 |
| Issue: | 8010 |
| ISSN: | 0028-0836 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2024-05-02 |
| Start Page: | 193 |
| End Page: | 200 |
| Language: | English |
| DOI: | 10.1038/s41586-024-07291-6 |
| PUBMED: | 38600383 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Erratum issued, see DOI: 10.1038/s41586-024-07654-z -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work