A user's guide and summary of Pediatric Normal Tissue Effects in the Clinic (PENTEC): Radiation dose-volume response for adverse effects after childhood cancer therapy and future directions Review
| Authors: | Constine, L. S.; Marks, L. B.; Milano, M. T.; Ronckers, C. M.; Jackson, A.; Hudson, M. M.; Marcus, K. J.; Hodgson, D. C.; Hua, C. H.; Howell, R. M.; Marples, B.; Yorke, E.; Olch, A.; Bentzen, S. M. |
| Review Title: | A user's guide and summary of Pediatric Normal Tissue Effects in the Clinic (PENTEC): Radiation dose-volume response for adverse effects after childhood cancer therapy and future directions |
| Abstract: | Pediatric Normal Tissue Effects in the Clinic (PENTEC) is an international multidisciplinary effort that aims to summarize normal-tissue toxicity risks based on published dose-volume data from studies of children and adolescents treated with radiation therapy (RT) for cancer. With recognition that children are uniquely vulnerable to treatment-related toxic effects, our mission and challenge was to assemble our group of physicians (radiation and pediatric oncologists, subspecialists), physicists with clinical and modeling expertise, epidemiologists, and other scientists to develop evidence-based radiation dosimetric guidelines, as affected by developmental status and other factors (eg, other cancer therapies and host factors). These quantitative toxicity risk estimates could serve to inform RT planning and thereby improve outcomes. Tandem goals included the description of relevant medical physics issues specific to pediatric RT and the proposal of dose-volume outcome reporting standards to inform future studies. We created 19 organ-specific task forces and methodology to unravel the wealth of data from heterogeneous published studies. This report provides a high-level summary of PENTEC's genesis, methods, key findings, and associated concepts that affected our work and an explanation of how our findings may be interpreted and applied in the clinic. We acknowledge our predecessors in these efforts, and we pay homage to the children whose lives informed us and to future generations who we hope will benefit from this additional step in our path forward. © 2023 Elsevier Inc. |
| Keywords: | adolescent; cancer chemotherapy; child; preschool child; child, preschool; cancer radiotherapy; radiation dose; antineoplastic agent; neoplasm; neoplasms; radiotherapy dosage; evidence based practice; editorial; practice guideline; radiation injury; risk factor; childhood cancer; radiation response; risk assessment; dose-response relationship, radiation; adverse outcome; infant; radiation dose fractionation; radiation injuries; medical specialist; radiobiology; radiation toxicity; organs at risk; predictive model; humans; human; apparent life threatening event; radiation dose response; pediatric oncologist |
| Journal Title: | International Journal of Radiation Oncology, Biology, Physics |
| Volume: | 119 |
| Issue: | 2 |
| ISSN: | 0360-3016 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2024-06-01 |
| Start Page: | 321 |
| End Page: | 337 |
| Language: | English |
| DOI: | 10.1016/j.ijrobp.2023.09.005 |
| PUBMED: | 37999712 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- MSK Cancer Center Support Grant (P30 CA008748) acknowledged in PDF -- Source: Scopus |
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