Penile-scrotal erythrodysesthesia among rectal cancer patients receiving fluoropyrimidine-based chemoradiation: A case report series Journal Article
| Authors: | Adames, A.; Roth O'Brien, D.; Kelly, A. R.; Saltz, L. B.; Garcia-Aguilar, J.; Zinovoy, M.; Williams, V.; Wu, A.; Reyngold, M.; Hajj, C.; Crane, C.; Cercek, A.; Smith, J. J.; Markova, A.; Cuaron, J.; McCann, P.; Romesser, P. B. |
| Article Title: | Penile-scrotal erythrodysesthesia among rectal cancer patients receiving fluoropyrimidine-based chemoradiation: A case report series |
| Abstract: | Background: Palmar-plantar erythrodysesthesia (PPE) is a slowly developing cutaneous reaction commonly experienced by patients treated with fluoropyrimidines. While erythrodysesthesia normally presents in a palmar-plantar distribution, it can also present with genital involvement, but this presentation is likely underreported and incorrectly attributed to an acute reaction from radiation therapy. This article aims to define erythrodysesthesia of the penis and scrotum as a rare but significant side effect of capecitabine. Case presentation: We identified five cases of moderate to severe penis and scrotal erythrodysesthesia over a 2-year period at a large tertiary cancer center, representing an estimated incidence of 3.6% among male patients with rectal cancer who were treated with fluoropyrimidine-based chemoradiation within our institution. Conclusions: Improved understanding of erythrodysesthesia involving the penis and scrotum can facilitate early identification and treatment of symptoms, and possibly prevent the discontinuation or delay of cancer treatment in patients treated with capecitabine and similar drugs. These clinical advances would improve and prolong patient quality of life during cancer treatment and prevent complications that result in hospitalization. © The Author(s) 2024. |
| Keywords: | adult; clinical article; aged; middle aged; case report; bevacizumab; fluorouracil; drug dose reduction; drug withdrawal; capecitabine; radiation dose; cancer staging; multiple cycle treatment; pathology; radiation response; irinotecan; skin exfoliation; conservative treatment; celecoxib; folinic acid; mismatch repair; erythema; hyperpigmentation; daily life activity; morphine; drug therapy; oxaliplatin; hand foot syndrome; hemicolectomy; rectal neoplasms; rectum cancer; rectum tumor; visual disorder; fluoropyrimidine; disease exacerbation; therapy; scrotum; skin care; chemoradiotherapy; penis; desquamation; rectal cancer; clobetasol; triamcinolone; conformal radiotherapy; rectal adenocarcinoma; adverse event; adenocarcinoma in situ; scrotal pain; neoadjuvant chemoradiation; sulfadiazine silver; very elderly; humans; human; male; article; aloe vera; bacitracin; supportive care need; penile erythrodysesthesia; scrotal erythrodysesthesia; toxic erythema of chemotherapy; penile swelling |
| Journal Title: | International Journal of Colorectal Disease |
| Volume: | 39 |
| ISSN: | 0179-1958 |
| Publisher: | Springer |
| Date Published: | 2024-05-23 |
| Start Page: | 75 |
| Language: | English |
| DOI: | 10.1007/s00384-024-04647-2 |
| PUBMED: | 38780794 |
| PROVIDER: | scopus |
| PMCID: | PMC11116207 |
| DOI/URL: | |
| Notes: | Article -- MSK Cancer Center Support Grant (P30 CA008748) acknowledged in PubMed and PDF -- MSK corresponding author is Paul Romesser -- Source: Scopus |
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