Trends in specific procedures performed at the time of cytoreduction for ovarian cancer: Is interval debulking surgery truly less radical? A Memorial Sloan Kettering Cancer Center Team Ovary study Journal Article
| Authors: | Filippova, O. T.; Boecking, K.; Broach, V.; Gardner, G. J.; Sonoda, Y.; Chi, D. S.; Zivanovic, O.; Long Roche, K. |
| Article Title: | Trends in specific procedures performed at the time of cytoreduction for ovarian cancer: Is interval debulking surgery truly less radical? A Memorial Sloan Kettering Cancer Center Team Ovary study |
| Abstract: | Objectives: To evaluate procedures performed during primary debulking surgery (PDS) and interval debulking surgery (IDS) for ovarian cancer. Methods: Patients surgically treated at our institution for newly diagnosed stage IIIC/IV epithelial ovarian cancer between 6/1/2015–12/31/2021 were identified using a prospectively collected database. Patients were triaged to PDS or neoadjuvant chemotherapy (NACT) followed by IDS using an institutional algorithm. Data on specific procedures performed, including consultants called, were collected from operative and pathology reports. Appropriate statistical analyses were applied. Results: Overall, 467 patients underwent PDS and 434 underwent IDS; 76% (PDS) and 71% (IDS) of cases achieved complete gross resection. Comparing PDS vs IDS cohorts, median age was 63 years (range, 23–86) vs 67 years (range, 35–95), 79% vs 86% of patients had high-grade serous histology, and 38% vs 70% had stage IV disease. Most procedures (except ostomy, distal pancreatectomy) were more common during PDS (P < .05). Bowel surgery was performed during 65% of PDS and 33% of IDS, and upper abdominal surgery during 72% of PDS and 52% of IDS; both were more common during PDS (P < .001). Estimated blood loss (median, 500 mL [PDS] vs 300 mL [IDS]) and operative time (median, 362 min [PDS] vs 267 min [IDS]) were higher for PDS (P < .001). A consulting surgeon was utilized during 31% of PDS and 18% of IDS, with hepatopancreaticobiliary as the most commonly called service (61% and 65%, respectively). Conclusions: In our study of patients with advanced-stage ovarian cancer, while most procedures were more often performed during PDS, NACT did not obviate the need for radical surgical resection. Thus, advanced surgical skills remain essential. © 2024 Elsevier Inc. |
| Keywords: | adult; controlled study; aged; cancer surgery; surgical technique; major clinical study; histopathology; postoperative period; cancer patient; cancer staging; cancer diagnosis; cancer grading; ovarian cancer; cytoreductive surgery; ovary cancer; cohort analysis; age; operation duration; ovary carcinoma; neoadjuvant chemotherapy; cytoreduction; abdominal surgery; intestine surgery; radical surgery; primary debulking surgery; interval debulking surgery; operative blood loss; human; female; article |
| Journal Title: | Gynecologic Oncology |
| Volume: | 187 |
| ISSN: | 0090-8258 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2024-08-01 |
| Start Page: | 80 |
| End Page: | 84 |
| Language: | English |
| DOI: | 10.1016/j.ygyno.2024.05.009 |
| PUBMED: | 38735143 |
| PROVIDER: | scopus |
| PMCID: | PMC12002067 |
| DOI/URL: | |
| Notes: | Article -- MSK Cancer Center Support Grant (P30 CA008748) acknowledged in PDF -- MSK corresponding author is Kara Long Roche -- Source: Scopus |
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