All that is small is not a small-cell carcinoma: Thoracic SMARCA4-deficient undifferentiated tumors masquerading as SCLC Journal Article
| Author: | Rekhtman, N. |
| Article Title: | All that is small is not a small-cell carcinoma: Thoracic SMARCA4-deficient undifferentiated tumors masquerading as SCLC |
| Abstract: | Small-cell lung carcinoma (SCLC) cell lines have been widely utilized as a preclinical model of this highly aggressive disease. However, since their creation decades ago, novel tumor entities have been defined that might clinicopathologically mimic SCLC, which notably includes thoracic SMARCA4-deficient undifferentiated tumor (SMARCA4-UT). Multiomic reassessment of the presumed SCLC cell lines with high YAP1 expression reveals that nearly all of these tumors represent unsuspected SMARCA4-UT. © 2024 American Association for Cancer Research. |
| Keywords: | adult; controlled study; human tissue; middle aged; unclassified drug; human cell; genetics; histopathology; biological marker; phenotype; diagnosis, differential; nuclear protein; lung neoplasms; differential diagnosis; prevalence; transcription factor; pathology; cell line, tumor; transcriptomics; carcinogenesis; transcription factors; nuclear proteins; thoracic neoplasms; lung tumor; tumor cell line; nerve cell adhesion molecule; chromogranin; transcription factor yap1; transcription factor sox2; dna helicases; dna helicase; nerve cell adhesion molecule l1; neuroendocrine carcinoma; small cell carcinoma; small cell lung cancer; small cell lung carcinoma; non small cell lung cancer; cd56 antigen; brg1 protein; cancer prognosis; humans; human; article; smarca4 protein, human; rhabdoid tumor cell line; tumor mutational burden; thoracic tumor; amylin derivative; insulinoma associated 1; neural cell adhesion molecule 1; spalt like transcription factor 4 |
| Journal Title: | Clinical Cancer Research |
| Volume: | 30 |
| Issue: | 9 |
| ISSN: | 1078-0432 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 2024-05-01 |
| Start Page: | 1708 |
| End Page: | 1711 |
| Language: | English |
| DOI: | 10.1158/1078-0432.Ccr-24-0227 |
| PUBMED: | 38416596 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- MSK Cancer Center Support Grant (P30 CA008748) acknowledged in PubMed and PDF -- MSK corresponding author is Natasha Rekhtman -- Source: Scopus |
