Symptom clusters and their impact on quality of life in multiple myeloma survivors: Secondary analysis of BMT CTN 0702 trial Journal Article
| Authors: | Brazauskas, R.; Flynn, K.; Krishnan, A.; Landau, H.; Giralt, S.; Pasquini, M. C.; Stadtmauer, E. A.; D'Souza, A. |
| Article Title: | Symptom clusters and their impact on quality of life in multiple myeloma survivors: Secondary analysis of BMT CTN 0702 trial |
| Abstract: | Autologous haematopoietic cell transplantation (autoHCT) and continuous post-transplant maintenance therapy are the standard of care in transplant-eligible multiple myeloma (MM) patients. We sought to describe symptom burden and identify symptom clusters occurring in MM patients after autoHCT using data from the BMT CTN 0702 randomized controlled trial comparing the outcomes of three treatment interventions after an autoHCT in 758 MM patients. We analysed individual transplant-related symptoms assessed via the FACT-BMT questionnaire at enrolment and annually for 4-year post-autoHCT. We also described the effect the individual symptoms and symptom clusters have on quality of life (QoL). We identified three stable symptom clusters: malaise symptom cluster (lack of energy, feeling ill, having pain, experiencing nausea, loss of appetite), physical symptom cluster (having skin problems, tremors, worsening eyesight, change in taste, shortness of breath, frequent colds) and emotional symptom cluster (feeling sad, being nervous, experiencing sleep problems). Malaise and emotional symptom clusters have a greater impact on QoL than the physical symptoms cluster. Identifying these symptoms warrant additional support in terms of psychosocial support, in addition to treatment of the physical symptoms themselves. © 2024 British Society for Haematology and John Wiley & Sons Ltd. |
| Keywords: | adult; controlled study; middle aged; major clinical study; overall survival; lenalidomide; clinical trial; progression free survival; quality of life; bortezomib; multiple myeloma; pain; nausea; randomized controlled trial; maintenance therapy; psychology; dexamethasone; hematopoietic stem cell transplantation; survivor; survivors; health care quality; questionnaire; malaise; body mass; karnofsky performance status; syndrome; psychosocial care; phase 3 clinical trial; randomization; socioeconomics; sample size; secondary analysis; clinical outcome; patient-reported outcome; symptom burden; humans; human; male; female; article; loss of appetite; symptom clusters |
| Journal Title: | British Journal of Haematology |
| Volume: | 204 |
| Issue: | 4 |
| ISSN: | 0007-1048 |
| Publisher: | John Wiley & Sons |
| Date Published: | 2024-04-01 |
| Start Page: | 1429 |
| End Page: | 1438 |
| Language: | English |
| DOI: | 10.1111/bjh.19326 |
| PUBMED: | 38348544 |
| PROVIDER: | scopus |
| PMCID: | PMC11006567 |
| DOI/URL: | |
| Notes: | Article -- Source: Scopus |
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