A somatic BRCA2-mutated pancreatic adenocarcinoma with sustained exceptional response to modified FOLFIRINOX Journal Article
| Authors: | Jamison, J. K.; May, M. S.; Raufi, A. G.; Luk, L.; Wong, W.; Mundi, P. S.; Manji, G. A. |
| Article Title: | A somatic BRCA2-mutated pancreatic adenocarcinoma with sustained exceptional response to modified FOLFIRINOX |
| Abstract: | Homologous recombination repair (HRR) pathway deficiency opens multiple therapeutic avenues within pancreatic cancer. Patients with HRR deficiency-associated gene mutations such as BRCA1, BRCA2, and PALB2 are more susceptible to platinum-based chemotherapies and in those with somatic BRCA mutations, PARP inhibitor therapy prolongs progression-free survival. The case discussed herein illustrates the therapeutic opportunities offered through the identification of HRR deficiency in pancreatic cancer, as well as the challenges associated with treatment and prevention of central nervous system metastases in long-term survivors of pancreatic cancer. © The Author(s) 2024. |
| Keywords: | immunohistochemistry; adult; cancer chemotherapy; clinical article; human tissue; treatment response; middle aged; somatic mutation; genetics; fatigue; case report; fluorouracil; cancer growth; pancreas cancer; pancreatic neoplasms; nuclear magnetic resonance imaging; antineoplastic agent; adenocarcinoma; progression free survival; computer assisted tomography; antineoplastic combined chemotherapy protocols; ca 19-9 antigen; epidermal growth factor receptor 2; brca1 protein; brca2 protein; protein p53; cancer survivor; irinotecan; abdominal pain; liver metastasis; folinic acid; pancreas tumor; brain metastasis; pancreas adenocarcinoma; platinum; pancreatic cancer; oxaliplatin; gamma knife radiosurgery; k ras protein; leucovorin; cancer survivors; central nervous system metastasis; brain damage; germline mutation; high throughput sequencing; brca2 protein, human; endoscopic ultrasound guided fine needle biopsy; recombination repair; humans; human; male; article; precision medicine; folfirinox; homologous recombination deficiency; partner and localizer of brca2 |
| Journal Title: | The Oncologist |
| Volume: | 29 |
| Issue: | 4 |
| ISSN: | 1083-7159 |
| Publisher: | Oxford University Press |
| Date Published: | 2024-04-01 |
| Start Page: | 350 |
| End Page: | 355 |
| Language: | English |
| DOI: | 10.1093/oncolo/oyad315 |
| PUBMED: | 38394390 |
| PROVIDER: | scopus |
| PMCID: | PMC10994267 |
| DOI/URL: | |
| Notes: | Source: Scopus |
