Impact of neoadjuvant chemotherapy on short-term outcomes after simple and complex minimally invasive minor hepatectomy for colorectal liver metastases: A propensity-score matched and coarsened exact matched study Journal Article
| Authors: | Hoogteijling, T. J.; Abu Hilal, M.; Zimmitti, G.; Aghayan, D. L.; Wu, A. G. R.; Cipriani, F.; Gruttadauria, S.; Scatton, O.; Long, T. C. D.; Herman, P.; Marino, M. V.; Mazzaferro, V.; Chiow, A. K. H.; Sucandy, I.; Ivanecz, A.; Choi, S. H.; Lee, J. H.; Gastaca, M.; Vivarelli, M.; Giuliante, F.; Ruzzenente, A.; Yong, C. C.; Yin, M.; Fondevila, C.; Efanov, M.; Morise, Z.; Di Benedetto, F.; Brustia, R.; Dalla Valle, R.; Boggi, U.; Geller, D.; Belli, A.; Memeo, R.; Mejia, A.; Park, J. O.; Rotellar, F.; Choi, G. H.; Robles-Campos, R.; Wang, X.; Sutcliffe, R. P.; Pratschke, J.; Tang, C. N.; Chong, C. C. N.; D'Hondt, M.; Monden, K.; Lopez-Ben, S.; Kingham, T. P.; Ferrero, A.; Ettorre, G. M.; Cherqui, D.; Liang, X.; Soubrane, O.; Wakabayashi, G.; Troisi, R. I.; Han, H. S.; Cheung, T. T.; Sugioka, A.; Dokmak, S.; Chen, K. H.; Liu, R.; Fuks, D.; Zhang, W.; Aldrighetti, L.; Edwin, B.; Goh, B. K. P.; International robotic and laparoscopic liver resection study group investigators |
| Article Title: | Impact of neoadjuvant chemotherapy on short-term outcomes after simple and complex minimally invasive minor hepatectomy for colorectal liver metastases: A propensity-score matched and coarsened exact matched study |
| Abstract: | Background: In the last three decades, minimally invasive liver resection has been replacing conventional open approach in liver surgery. More recently, developments in neoadjuvant chemotherapy have led to increased multidisciplinary management of colorectal liver metastases with both medical and surgical treatment modalities. However, the impact of neoadjuvant chemotherapy on the surgical outcomes of minimally invasive liver resections remains poorly understood. Methods: A multicenter, international, database of 4998 minimally invasive minor hepatectomy for colorectal liver metastases was used to compare surgical outcomes in patients who received neoadjuvant chemotherapy with surgery alone. To correct for baseline imbalance, propensity score matching, coarsened exact matching and inverse probability treatment weighting were performed. Results: 2546 patients met the inclusion criteria. After propensity score matching there were 759 patients in both groups and 383 patients in both groups after coarsened exact matching. Baseline characteristics were equal after both matching strategies. Neoadjuvant chemotherapy was not associated with statistically significant worse surgical outcomes of minimally invasive minor hepatectomy. Conclusion: Neoadjuvant chemotherapy had no statistically significant impact on short-term surgical outcomes after simple and complex minimally invasive minor hepatectomy for colorectal liver metastases. © 2024 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology |
| Keywords: | adult; controlled study; treatment outcome; aged; surgical technique; major clinical study; case control study; postoperative period; cancer patient; comparative study; antineoplastic agent; morbidity; cohort analysis; retrospective study; length of stay; operation duration; blood transfusion; surgical mortality; minimally invasive surgery; hepatectomy; neoadjuvant chemotherapy; colorectal liver metastases; metastasis resection; propensity score; colorectal liver metastasis; pringle maneuver; conversion to open surgery; operative blood loss; human; male; female; article; difficulty score; minimally invasive liver surgery; minor surgery; coarsened exact-matched; inverse probability treatment weighting; minor hepatectomy; propensity-score matched; minimally invasive minor hepatectomy |
| Journal Title: | European Journal of Surgical Oncology |
| Volume: | 50 |
| Issue: | 6 |
| ISSN: | 0748-7983 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2024-06-01 |
| Start Page: | 108309 |
| Language: | English |
| DOI: | 10.1016/j.ejso.2024.108309 |
| PROVIDER: | scopus |
| PUBMED: | 38626588 |
| DOI/URL: | |
| Notes: | Article -- Source: Scopus |
