Impact of teratoma on survival probabilities of patients with metastatic non-seminomatous germ cell cancer: Results from the IGCCCG Update Consortium Journal Article
| Authors: | Bührer, E.; D'Haese, D.; Daugaard, G.; de Wit, R.; Albany, C.; Tryakin, A.; Fizazi, K.; Stahl, O.; Gietema, J. A.; De Giorgi, U.; Cafferty, F. H.; Hansen, A. R.; Tandstad, T.; Huddart, R. A.; Necchi, A.; Sweeney, C. J.; Garcia-Del-Muro, X.; Heng, D. Y. C.; Lorch, A.; Chovanec, M.; Winquist, E.; Grimison, P.; Feldman, D. R.; Terbuch, A.; Hentrich, M.; Bokemeyer, C.; Negaard, H.; Fankhauser, C.; Shamash, J.; Vaughn, D. J.; Sternberg, C. N.; Heidenreich, A.; Collette, L.; Gillessen, S.; Beyer, J. |
| Article Title: | Impact of teratoma on survival probabilities of patients with metastatic non-seminomatous germ cell cancer: Results from the IGCCCG Update Consortium |
| Abstract: | Aims: To resolve the ongoing controversy surrounding the impact of teratoma (TER) in the primary among patients with metastatic testicular non-seminomatous germ-cell tumours (NSGCT). Patients and methods: Using the International Germ Cell Cancer Collaborative Group (IGCCCG) Update Consortium database, we compared the survival probabilities of patients with metastatic testicular GCT with TER (TER) or without TER (NTER) in their primaries corrected for known prognostic factors. Progression-free survival (5y-PFS) and overall survival at 5 years (5y-OS) were estimated by the Kaplan-Meier method. Results: Among 6792 patients with metastatic testicular NSGCT, 3224 (47%) had TER in their primary, and 3568 (53%) did not. In the IGCCCG good prognosis group, the 5y-PFS was 87.8% in TER versus 92.0% in NTER patients (p = 0.0001), the respective 5y-OS were 94.5% versus 96.5% (p = 0.0032). The corresponding figures in the intermediate prognosis group were 5y-PFS 76.9% versus 81.6% (p = 0.0432) in TER and NTER and 5y-OS 90.4% versus 90.9% (p = 0.8514), respectively. In the poor prognosis group, there was no difference, neither in 5y-PFS [54.3% in TER patients versus 55.4% (p = 0.7472) in NTER], nor in 5y-OS [69.4% versus 67.7% (p = 0.3841)]. NSGCT patients with TER had more residual masses (65.3% versus 51.7%, p < 0.0001), and therefore received post-chemotherapy surgery more frequently than NTER patients (46.8% versus 32.0%, p < 0.0001). Conclusion: Teratoma in the primary tumour of patients with metastatic NSGCT negatively impacts on survival in the good and intermediate, but not in the poor IGCCCG prognostic groups. © 2024 |
| Keywords: | adult; cancer chemotherapy; controlled study; primary tumor; survival rate; retrospective studies; major clinical study; overall survival; cisplatin; paclitaxel; metastasis; progression free survival; multiple cycle treatment; etoposide; cohort analysis; risk factors; retrospective study; risk factor; ifosfamide; testis tumor; testicular neoplasms; bleomycin; teratoma; neoplasms, germ cell and embryonal; kaplan meier method; seminoma; non seminomatous germinoma; cancer prognosis; humans; prognosis; human; male; article; testicular germ cell tumor; igcccg; germ cell and embryonal neoplasms; germ-cell tumours; non-seminoma |
| Journal Title: | European Journal of Cancer |
| Volume: | 202 |
| ISSN: | 0959-8049 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2024-05-01 |
| Start Page: | 114042 |
| Language: | English |
| DOI: | 10.1016/j.ejca.2024.114042 |
| PUBMED: | 38564927 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Source: Scopus |
