Radiomodulating properties of superparamagnetic iron oxide nanoparticle (SPION) agent ferumoxytol on human monocytes: Implications for MRI-guided liver radiotherapy Journal Article
| Authors: | Shurin, M. R.; Kirichenko, V. A.; Shurin, G. V.; Lee, D.; Crane, C.; Kirichenko, A. V. |
| Article Title: | Radiomodulating properties of superparamagnetic iron oxide nanoparticle (SPION) agent ferumoxytol on human monocytes: Implications for MRI-guided liver radiotherapy |
| Abstract: | Superparamagnetic iron oxide nanoparticles (SPION) have attracted great attention not only for therapeutic applications but also as an alternative magnetic resonance imaging (MRI) contrast agent that helps visualize liver tumors during MRI-guided stereotactic body radiotherapy (SBRT). SPION can provide functional imaging of liver parenchyma based upon its uptake by the hepatic resident macrophages or Kupffer cells with a relative enhancement of malignant tumors that lack Kupffer cells. However, the radiomodulating properties of SPION on liver macrophages are not known. Utilizing human monocytic THP-1 undifferentiated and differentiated cells, we characterized the effect of ferumoxytol (Feraheme®), a carbohydrate-coated ultrasmall SPION agent at clinically relevant concentration and therapeutically relevant doses of gamma radiation on cultured cells in vitro. We showed that ferumoxytol affected both monocytes and macrophages, increased the resistance of monocytes to radiation-induced cell death and inhibition of cell activity, and supported the anti-inflammatory phenotype of human macrophages under radiation. Its effect on human cells depended on the duration of SPION uptake and was radiation dose-dependent. The results of this pilot study support a strong mechanism-based optimization of SPION-enhanced MRI-guided liver SBRT for primary and metastatic liver tumors, especially in patients with liver cirrhosis awaiting a liver transplant. © 2024 by the authors. |
| Keywords: | platelet derived growth factor; vasculotropin; controlled study; human cell; liver cirrhosis; liver transplantation; flow cytometry; nuclear magnetic resonance imaging; phenotype; interleukin 2; apoptosis; granulocyte macrophage colony stimulating factor; interleukin 10; interleukin 12p70; interleukin 13; interleukin 1beta; interleukin 4; interleukin 5; interleukin 7; interleukin 8; macrophage inflammatory protein 1beta; fibroblast growth factor 2; gamma interferon; liver tumor; irradiation; interleukin 6; kupffer cell; liver cancer; monocyte; monocytes; macrophage; macrophages; cytokine release; liver parenchyma; stereotactic body radiation therapy; granulocyte colony stimulating factor; cell activity; monocyte chemotactic protein 1; modulation; gamma radiation; rantes; ferumoxytol; medical procedures; macrophage inflammatory protein 1alpha; superparamagnetic iron oxide nanoparticle; biomedical application; human; article; mtt assay; malignant neoplasm; cell proliferation assay; thp-1 cell line; magnetic iron oxide nanoparticles; allograft inflammatory factor 1; nagrestipen; liver radiotherapy; radiomodulation |
| Journal Title: | Cancers |
| Volume: | 16 |
| Issue: | 7 |
| ISSN: | 2072-6694 |
| Publisher: | MDPI |
| Date Published: | 2024-04-01 |
| Start Page: | 1318 |
| Language: | English |
| DOI: | 10.3390/cancers16071318 |
| PROVIDER: | scopus |
| PMCID: | PMC11011128 |
| PUBMED: | 38610996 |
| DOI/URL: | |
| Notes: | Article -- Source: Scopus |
