A general approach to patients presenting with locally advanced or distant metastatic disease Review
| Authors: | Smithy, J. W.; Chapman, P. B. |
| Review Title: | A general approach to patients presenting with locally advanced or distant metastatic disease |
| Abstract: | The widespread adoption of immune checkpoint inhibitors and small molecule inhibitors of the MAP kinase pathway has transformed the management of locally advanced and metastatic melanoma. Here, we provide a broad overview on the use of these agents in the first-line setting, incorporating a review of the clinical literature as well as the practice patterns of our respective melanoma groups. Throughout, we highlight areas of uncertainty that provide opportunities for future clinical investigation and additional improvement in outcomes for patients with melanoma. © Wolters Kluwer Health, Inc. All rights reserved. |
| Keywords: | cancer surgery; gene mutation; review; advanced cancer; outcome assessment; ipilimumab; cancer immunotherapy; melanoma; skin neoplasms; pathology; distant metastasis; skin tumor; immunotherapy; targeted therapy; b raf kinase; mitogen activated protein kinase kinase; neoadjuvant; braf mutation; brain metastases; adjuvant; vemurafenib; immune checkpoint inhibitor; dabrafenib; nivolumab; humans; human; pembrolizumab; immune checkpoint inhibitors; checkpoint inhibition; immune checkpoint protein; checkpoint inhibitor therapy |
| Journal Title: | The Cancer Journal |
| Volume: | 30 |
| Issue: | 2 |
| ISSN: | 1528-9117 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2024-03-01 |
| Start Page: | 48 |
| End Page: | 53 |
| Language: | English |
| DOI: | 10.1097/ppo.0000000000000704 |
| PUBMED: | 38527257 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Source: Scopus |
