SWI/SNF regulation of germinal center fate and lymphomagenesis Editorial

  


Authors: Sievers, Q.; Abdel-Wahab, O.
Title: SWI/SNF regulation of germinal center fate and lymphomagenesis
Abstract: The mSWI/SNF subunits ARID1A and SMARCA4 are mutated in B cell lymphomas. Now, Barisic et al. and Deng et al. find that loss of ARID1A or SMARCA4 contributes to lymphomagenesis by causing B cells to aberrantly re-enter germinal centers where they undergo repeated rounds of proliferation and somatic hypermutation. © 2024 Elsevier Inc.
Keywords: unclassified drug; gene mutation; genetics; missense mutation; nonhuman; note; gene expression; nuclear protein; protein; transcription factor; transcription factors; nuclear proteins; germinal center; somatic hypermutation; lymph node; loss of function mutation; dna helicases; dna helicase; enzyme active site; nucleosome; protein swi; transcription factor snf; brg1 protein; lymphomagenesis; humans; human; arid1a protein; smarca4 protein, human
Journal Title: Cancer Cell
Volume: 42
Issue: 4
ISSN: 1535-6108
Publisher: Cell Press  
Date Published: 2024-04-08
Start Page: 507
End Page: 509
Language: English
DOI: 10.1016/j.ccell.2024.02.006
PUBMED: 38458185
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85189513013&doi=10.1016%2fj.ccell.2024.02.006&partnerID=40&md5=d9c94fe7cbbff28c8c5d6110d794964f
Notes: Note -- Source: Scopus
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MSK Authors
  1. Omar Ibrahim Abdel-Wahab
    573 Abdel-Wahab
  2. Quinlan Sievers
    2 Sievers
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