Updates on urinary bladder tumors with neuroendocrine features Review
| Authors: | Akbulut, D.; Al-Ahmadie, H. |
| Review Title: | Updates on urinary bladder tumors with neuroendocrine features |
| Abstract: | The most common neuroendocrine tumor in the urinary bladder is small cell carcinoma, which can be pure or mixed with components of urothelial or other histologic subtypes. Large cell neuroendocrine carcinoma of the bladder is rare and remains ill-defined but is increasingly recognized. Well-differentiated neuroendocrine tumor and paraganglioma can arise in the bladder but are very rare in this location. Recent advances in molecular characterization allowed for better classification and may offer improved stratification of these tumors. © 2024 Wolters Kluwer Health, Inc. All rights reserved. |
| Keywords: | immunohistochemistry; signal transduction; protein expression; gene mutation; overall survival; histopathology; review; disease free survival; cd8+ t lymphocyte; paraganglioma; microrna; pathology; bladder cancer; fibroblast growth factor receptor 3; protein p53; uvomorulin; bladder tumor; urinary bladder neoplasms; histology; neuroendocrine tumor; prostate cancer; urothelium; fluorescence in situ hybridization; systematic review; cystectomy; urinary bladder; upregulation; neoadjuvant chemotherapy; bladder carcinoma; transitional cell carcinoma; neuroendocrine tumors; neuroendocrine carcinoma; small cell carcinoma; carcinoma, neuroendocrine; bladder; insulinoma; large cell neuroendocrine carcinoma; epithelial mesenchymal transition; germline mutation; notch signaling; cancer prognosis; neuroendocrine system; humans; human; ascl1; well-differentiated neuroendocrine tumor; neurod1; pou2f3 |
| Journal Title: | Advances in Anatomic Pathology |
| Volume: | 31 |
| Issue: | 3 |
| ISSN: | 1072-4109 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2024-05-01 |
| Start Page: | 169 |
| End Page: | 177 |
| Language: | English |
| DOI: | 10.1097/pap.0000000000000433 |
| PUBMED: | 38523484 |
| PROVIDER: | scopus |
| PMCID: | PMC11006587 |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PDF -- Corresponding author is MSK author: Hikmat Al-Ahmadie -- Source: Scopus |
