Novel computerized neurocognitive test battery is sensitive to cancer-related cognitive deficits in survivors Journal Article
| Authors: | Gaynor, A. M.; Ahsan, A.; Jung, D.; Schofield, E.; Li, Y.; Ryan, E.; Ahles, T. A.; Root, J. C. |
| Article Title: | Novel computerized neurocognitive test battery is sensitive to cancer-related cognitive deficits in survivors |
| Abstract: | Purpose: There is increasing interest in developing new methods to improve sensitivity in detecting subtle cognitive deficits associated with cancer and its treatments. The current study aimed to evaluate the ability of a novel computerized battery of cognitive neuroscience–based tests to discriminate between cognitive performance in breast cancer survivors and controls. Methods: Breast cancer survivors (N = 174) and age-matched non-cancer controls (N = 183) completed the Enformia Cogsuite Battery of cognitive assessments, comprised of 7 computerized tests of multiple cognitive domains. Primary outcome measures included accuracy, reaction times (RT), and coefficients of variation (CV) for each task, as well as global scores of accuracy, RT, and CV aggregated across tests. Results: Linear regressions adjusting for age, education, and remote vs. in-office administration showed that compared to non-cancer controls, survivors had significantly lower performance on measures of attention, executive function, working memory, verbal ability, visuospatial ability, and motor function. Survivors had significantly greater CV on measures of attention, working memory, and processing speed, and significantly slower RT on measures of verbal fluency. Conclusions: The Cogsuite battery demonstrates sensitivity to cancer-related cognitive dysfunction across multiple domains, and is capable of identifying specific cognitive processes that may be affected in survivors. Implications for Cancer Survivors: The sensitivity of these tasks to subtle cognitive deficits has advantages for initial diagnosis of cancer-related cognitive dysfunction, as well as detecting changes in survivors’ cognitive function over time. The remote delivery of the battery may help overcome barriers associated with in-office administration and increase access to neurocognitive evaluation. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022. |
| Keywords: | adult; clinical article; controlled study; breast cancer; survivor; cancer survivor; diagnosis; survivorship; cognition; cognitive defect; cross-sectional study; cancer control; motor performance; mental performance; reaction time; working memory; cognitive impairment; executive function; human; male; female; article; malignant neoplasm; processing speed; cancer-related cognitive dysfunction |
| Journal Title: | Journal of Cancer Survivorship |
| Volume: | 18 |
| Issue: | 2 |
| ISSN: | 1932-2259 |
| Publisher: | Springer |
| Date Published: | 2024-04-01 |
| Start Page: | 466 |
| End Page: | 478 |
| Language: | English |
| DOI: | 10.1007/s11764-022-01232-w |
| PUBMED: | 35939254 |
| PROVIDER: | scopus |
| PMCID: | PMC11274167 |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PDF -- Source: Scopus |
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