Prevalence of astrovirus and sapovirus among adult oncology patients with acute gastroenteritis using a multiplexed gastrointestinal pathogen PCR panel Journal Article
| Authors: | Cintron, M.; Jani, K.; Madhavappallil, J.; Kamboj, M.; Babady, N. E. |
| Article Title: | Prevalence of astrovirus and sapovirus among adult oncology patients with acute gastroenteritis using a multiplexed gastrointestinal pathogen PCR panel |
| Abstract: | Background: Multiplex syndromic gastrointestinal panels (GIPCR) have streamlined the diagnosis of infectious diarrhea. Additionally, they have expanded the number of pathogens that can be routinely evaluated, allowing further understanding of the prevalence of enteric pathogens in various patient populations. The goal of this study was to investigate the prevalence and clinical presentation of astrovirus and sapovirus gastroenteritis in adult oncology patients as detected by the FilmArray GIPCR. Methods: All GIPCR panel results from December 2017 to June 2021 were retrospectively reviewed to determine the prevalence of astrovirus and sapovirus in adult oncology patients. Medical records were also reviewed to obtain clinical information. Repeat GIPCR positivity and symptom duration were used to estimate prolonged viral shedding. Results: A total of 18,014 panels were performed on samples collected from 9303 adults. Overall, astrovirus and sapovirus were detected in 0.35% (33/9303) and 0.45% (42/9303) GIPCRs respectively. At least one viral target was detected in 424 (4.4%) patients. Astrovirus accounted for 7.8% (33/424) and sapovirus 9.9% (42/424) of patients. Diarrhea was the most common symptom documented. A subset of transplant patients had protracted viral detection with a median of ~27 days (range 23–43 days) for astrovirus and 97 days (range 11–495) for sapovirus. No clusters or outbreaks were identified during the study period. Conclusion: In oncology patients with viral gastroenteritis, astrovirus and sapovirus were the causative agents in 18% of the cases. Both viruses were associated with mild disease. Prolonged diarrhea and viral shedding were observed in a few transplant patients. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024. |
| Keywords: | adult; aged; retrospective studies; major clinical study; genetics; clinical feature; diarrhea; nonhuman; cancer patient; polymerase chain reaction; neoplasm; neoplasms; prevalence; medical record review; retrospective study; electronic medical record; symptom; patient information; infant; graft versus host reaction; nausea and vomiting; disease duration; observational study; feces; virus detection; gastroenteritis; astrovirus; norovirus; repeat procedure; complication; multiplex polymerase chain reaction; virus shedding; calicivirus infection; cancer; humans; human; male; female; article; chronic diarrhea; sapovirus; acute gastroenteritis; positivity rate; astrovirus infection; gipcr; astroviridae; sapovirus infection; viral gastroenteritis |
| Journal Title: | European Journal of Clinical Microbiology and Infectious Diseases |
| Volume: | 43 |
| Issue: | 3 |
| ISSN: | 0934-9723 |
| Publisher: | Springer |
| Date Published: | 2024-04-01 |
| Start Page: | 525 |
| End Page: | 531 |
| Language: | English |
| DOI: | 10.1007/s10096-024-04748-4 |
| PUBMED: | 38216845 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PDF -- Corresponding author is MSK author: N. Esther Babady -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
Related MSK Work