Sensitivity of urine cytology in detecting high-grade urothelial carcinoma in patients with neoplastic urinary bladder diverticula: A major cancer center experience Journal Article

   

Authors:	Alhamar, M.; Al-Ahmadie, H. A.; Feratovic, R.; Lin, O.
Article Title:	Sensitivity of urine cytology in detecting high-grade urothelial carcinoma in patients with neoplastic urinary bladder diverticula: A major cancer center experience
Abstract:	Background: Bladder diverticula are herniations of bladder urothelium and mucosa through the muscularis propria. The reported incidence of neoplasia arising in bladder diverticula is widely variable. The authors’ objective was to study the characteristics and sensitivity of urine cytology in these patients with emphasis on primary intradiverticular bladder cancer (IDBC). Methods: A 17-year, retrospective review of all resected bladder diverticula associated with bladder carcinoma was performed. Cases that had complete diverticular resections and preresection urine samples were included in this study. The cases were divided into either primary IDBC or primary extradiverticular bladder cancer (EDBC). Demographic data and urine cytology characteristics were recorded, and sensitivity was calculated. For IDBC, a comparison between voided and cystoscopic urines was done for cases that had both collection methods performed. Results: Of 70 patients with IDBC, 47 patients had urine cytology results that were either positive for high grade-urothelial carcinoma (HG-UC) or suspicious for HG-UC. The sensitivity for HG-UC in IDBC samples was 80%, compared with 82% in EDBC samples (p >.05). Also, 28 patients in the IDBC group had both voided and cystoscopic urine samples for comparisons; in seven patients, the voided urine sample yielded a more definitive diagnosis; in 10 patients, the cystoscopic urine sample yielded a more definitive diagnosis; and, in 11 patients, both samples were equally diagnostic (p >.05). Conclusions: The characteristics and sensitivity of urine cytology in bladder diverticula were investigated in association with neoplasia, with an emphasis on primary intradiverticular bladder cancer. The results indicated that urine cytology remains a reliable screening and diagnostic test for detecting IDBC, with sensitivity similar to that for detecting EDBC, and no significant difference was noted between voided and cystoscopic samples. © 2023 American Cancer Society.
Keywords:	adult; controlled study; aged; middle aged; major clinical study; sensitivity and specificity; sensitivity analysis; neoplasm; cytology; disease association; pathology; retrospective study; bladder cancer; bladder tumor; urinary bladder neoplasms; cancer center; urinary bladder; urine; carcinoma, transitional cell; bladder carcinoma; transitional cell carcinoma; bladder; urine cytology; diverticulum; urethra diverticulum; complication; demographics; diverticulosis; diverticula; very elderly; humans; human; male; female; article; bladder diverticulum; intradiverticular bladder cancer; urine sampling; extradiverticular; high-grade urothelial carcinoma; low-grade urothelial carcinoma
Journal Title:	Cancer Cytopathology
Volume:	132
Issue:	3
ISSN:	1934-662X
Publisher:	John Wiley & Sons
Date Published:	2024-03-01
Start Page:	144
End Page:	151
Language:	English
DOI:	10.1002/cncy.22782
PUBMED:	38054371
PROVIDER:	scopus
PMCID:	PMC10932867
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85178960920&doi=10.1002%2fcncy.22782&partnerID=40&md5=a3cc36e07bdaf87e9ada21cd913b13d7
Notes:	The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PDF -- Corresponding author is MSK author: Mohamed Alhama -- Source: Scopus

https://synapse.mskcc.org/synapse/works/has_related_data_chk/214808