Testicular cancer in 2023: Current status and recent progress Review
| Authors: | McHugh, D. J.; Gleeson, J. P.; Feldman, D. R. |
| Review Title: | Testicular cancer in 2023: Current status and recent progress |
| Abstract: | Testicular germ cell tumor (GCT) is the most common solid tumor in adolescent and young adult men. Progress in the management of GCT has been made in the last 50 years, with a substantial improvement in cure rates for advanced disease, from 25% in the 1970s to nearly 80%. However, relapsed or platinum-refractory disease occurs in a proportion, 20% of whom will die from disease progression. This article reviews the current evidence-based treatments for extracranial GCT, the acute and chronic toxic effects that may result, and highlights contemporary advances and progress in the field. © 2023 The Authors. CA: A Cancer Journal for Clinicians published by Wiley Periodicals LLC on behalf of American Cancer Society. |
| Keywords: | adolescent; event free survival; young adult; overall survival; neutropenia; paresthesia; review; cisplatin; advanced cancer; drug dose comparison; paclitaxel; adjuvant therapy; disease free survival; chemotherapy; cancer staging; drug megadose; positron emission tomography; antineoplastic agent; cancer incidence; lymph node dissection; paraaortic lymph node; carboplatin; progression free survival; multiple cycle treatment; etoposide; leukopenia; antineoplastic combined chemotherapy protocols; myalgia; peripheral neuropathy; cyclophosphamide; pathology; ifosfamide; vinblastine; cancer resistance; febrile neutropenia; pneumonia; active surveillance; dosage schedule comparison; tumor recurrence; fluorodeoxyglucose f 18; testis tumor; testicular neoplasms; bleomycin; genomics; lactate dehydrogenase; testicular cancer; neoplasms, germ cell and embryonal; orchiectomy; hypogonadism; oxaliplatin; erectile dysfunction; germ cell tumor; granulocyte colony stimulating factor; abdominal cramp; seminoma; phosphodiesterase v inhibitor; clinical trials; raynaud phenomenon; advanced; male infertility; ototoxicity; sperm preservation; cancer prognosis; long term survival; lymph vessel metastasis; drug dose intensification; humans; human; male; standardized mortality ratio; testicular germ cell tumor; germ cell and embryonal neoplasms; tumor mutational burden; nonseminomatous germ cell tumor of the testis |
| Journal Title: | CA - A Cancer Journal for Clinicians |
| Volume: | 74 |
| Issue: | 2 |
| ISSN: | 0007-9235 |
| Publisher: | Wiley-Blackwell |
| Date Published: | 2024-03-01 |
| Start Page: | 167 |
| End Page: | 186 |
| Language: | English |
| DOI: | 10.3322/caac.21819 |
| PUBMED: | 37947355 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Source: Scopus |
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